Genome-wide associations for birth weight and correlations with adult disease

M. Horikoshi; R.N. Beaumont; F.R. Day; N.M. Warrington; M.N. Kooijman; J. Fernandez-Tajes; B. Feenstra; N.R. van Zuydam; K.J. Gaulton; N. Grarup; J.J. Hottenga; N. Rahmioglu; DR Nyholt; C.E.M. van Beijsterveldt; G. Willemsen; E.J.C. de Geus; D.I. Boomsma; T.M. Frayling; G. Davey Smith; A.P. Morris; K.K. Ong; J.F. Felix; N.J. Timpson; J.R.B. Perry; D.M. Evans; M.I. McCarthy; R.M. Freathy

doi:10.1038/nature19806

Genome-wide associations for birth weight and correlations with adult disease

M. Horikoshi
, R.N. Beaumont
, F.R. Day
, N.M. Warrington
, M.N. Kooijman
, J. Fernandez-Tajes
, B. Feenstra
, N.R. van Zuydam
, K.J. Gaulton
, N. Grarup
, J.J. Hottenga
, N. Rahmioglu
, DR Nyholt
, C.E.M. van Beijsterveldt
, G. Willemsen
, E.J.C. de Geus
, D.I. Boomsma
, T.M. Frayling
, G. Davey Smith
, A.P. Morris

K.K. Ong, J.F. Felix, N.J. Timpson, J.R.B. Perry, D.M. Evans, M.I. McCarthy, R.M. Freathy

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease1. These lifecourse associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10

Original language	English
Pages (from-to)	248-252
Journal	Nature
Volume	538
Issue number	7624
DOIs	https://doi.org/10.1038/nature19806
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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10.1038/nature19806

https://www.ncbi.nlm.nih.gov/pmc/articles/5164934

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Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., Hottenga, J. J., Rahmioglu, N., Nyholt, DR., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Frayling, T. M., Davey Smith, G., ... Freathy, R. M. (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. https://doi.org/10.1038/nature19806

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title = "Genome-wide associations for birth weight and correlations with adult disease",

abstract = "Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease1. These lifecourse associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10",

author = "M. Horikoshi and R.N. Beaumont and F.R. Day and N.M. Warrington and M.N. Kooijman and J. Fernandez-Tajes and B. Feenstra and \{van Zuydam\}, N.R. and K.J. Gaulton and N. Grarup and J.J. Hottenga and N. Rahmioglu and DR Nyholt and \{van Beijsterveldt\}, C.E.M. and G. Willemsen and \{de Geus\}, E.J.C. and D.I. Boomsma and T.M. Frayling and \{Davey Smith\}, G. and A.P. Morris and K.K. Ong and J.F. Felix and N.J. Timpson and J.R.B. Perry and D.M. Evans and M.I. McCarthy and R.M. Freathy",

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doi = "10.1038/nature19806",

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Horikoshi, M, Beaumont, RN, Day, FR, Warrington, NM, Kooijman, MN, Fernandez-Tajes, J, Feenstra, B, van Zuydam, NR, Gaulton, KJ, Grarup, N, Hottenga, JJ, Rahmioglu, N, Nyholt, DR, van Beijsterveldt, CEM, Willemsen, G, de Geus, EJC , Boomsma, DI, Frayling, TM, Davey Smith, G, Morris, AP, Ong, KK, Felix, JF, Timpson, NJ, Perry, JRB, Evans, DM, McCarthy, MI & Freathy, RM 2016, 'Genome-wide associations for birth weight and correlations with adult disease', Nature, vol. 538, no. 7624, pp. 248-252. https://doi.org/10.1038/nature19806

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AU - Horikoshi, M.

AU - Beaumont, R.N.

AU - Day, F.R.

AU - Warrington, N.M.

AU - Kooijman, M.N.

AU - Fernandez-Tajes, J.

AU - Feenstra, B.

AU - van Zuydam, N.R.

AU - Gaulton, K.J.

AU - Grarup, N.

AU - Hottenga, J.J.

AU - Rahmioglu, N.

AU - Nyholt, DR

AU - van Beijsterveldt, C.E.M.

AU - Willemsen, G.

AU - de Geus, E.J.C.

AU - Boomsma, D.I.

AU - Frayling, T.M.

AU - Davey Smith, G.

AU - Morris, A.P.

AU - Ong, K.K.

AU - Felix, J.F.

AU - Timpson, N.J.

AU - Perry, J.R.B.

AU - Evans, D.M.

AU - McCarthy, M.I.

AU - Freathy, R.M.

PY - 2016

Y1 - 2016

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JF - Nature

IS - 7624

ER -

Genome-wide associations for birth weight and correlations with adult disease

Abstract

UN SDGs

Cohort Studies

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