Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

N. Rahmioglu, S. Macgregor, A.W. Drong, A.K. Hedman, H.R. Harris, J.C. Randall, I. Prokopenko, J.J. Hottenga, D.I. Boomsma, DR Nyholt, A.P. Morris, G.W. Montgomery, S.A. Missmer, C.M. Lindgren, K.T. Zondervan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis (P = 3.7 × 10
Original languageEnglish
Pages (from-to)1185-1199
Number of pages15
JournalHuman Molecular Genetics
Volume24
Issue number4
DOIs
Publication statusPublished - 2015

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