Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

N. Rahmioglu; S. Macgregor; A.W. Drong; A.K. Hedman; H.R. Harris; J.C. Randall; I. Prokopenko; J.J. Hottenga; D.I. Boomsma; DR Nyholt; A.P. Morris; G.W. Montgomery; S.A. Missmer; C.M. Lindgren; K.T. Zondervan

doi:10.1093/hmg/ddu516

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

N. Rahmioglu
, S. Macgregor
, A.W. Drong
, A.K. Hedman
, H.R. Harris
, J.C. Randall
, I. Prokopenko
, J.J. Hottenga
, D.I. Boomsma
, DR Nyholt
, A.P. Morris
, G.W. Montgomery
, S.A. Missmer
, C.M. Lindgren
, K.T. Zondervan

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis (P = 3.7 × 10

Original language	English
Pages (from-to)	1185-1199
Number of pages	15
Journal	Human Molecular Genetics
Volume	24
Issue number	4
DOIs	https://doi.org/10.1093/hmg/ddu516
Publication status	Published - 2015

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SDG 3 Good Health and Well-being

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10.1093/hmg/ddu516

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Rahmioglu, N., Macgregor, S., Drong, A. W., Hedman, A. K., Harris, H. R., Randall, J. C., Prokopenko, I., Hottenga, J. J., Boomsma, D. I., Nyholt, DR., Morris, A. P., Montgomery, G. W., Missmer, S. A., Lindgren, C. M., & Zondervan, K. T. (2015). Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Human Molecular Genetics, 24(4), 1185-1199. https://doi.org/10.1093/hmg/ddu516

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title = "Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci",

abstract = "Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis (P = 3.7 × 10",

author = "N. Rahmioglu and S. Macgregor and A.W. Drong and A.K. Hedman and H.R. Harris and J.C. Randall and I. Prokopenko and J.J. Hottenga and D.I. Boomsma and DR Nyholt and A.P. Morris and G.W. Montgomery and S.A. Missmer and C.M. Lindgren and K.T. Zondervan",

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Rahmioglu, N, Macgregor, S, Drong, AW, Hedman, AK, Harris, HR, Randall, JC, Prokopenko, I, Hottenga, JJ, Boomsma, DI, Nyholt, DR, Morris, AP, Montgomery, GW, Missmer, SA, Lindgren, CM & Zondervan, KT 2015, 'Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci', Human Molecular Genetics, vol. 24, no. 4, pp. 1185-1199. https://doi.org/10.1093/hmg/ddu516

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AU - Rahmioglu, N.

AU - Macgregor, S.

AU - Drong, A.W.

AU - Hedman, A.K.

AU - Harris, H.R.

AU - Randall, J.C.

AU - Prokopenko, I.

AU - Hottenga, J.J.

AU - Boomsma, D.I.

AU - Nyholt, DR

AU - Morris, A.P.

AU - Montgomery, G.W.

AU - Missmer, S.A.

AU - Lindgren, C.M.

AU - Zondervan, K.T.

PY - 2015

Y1 - 2015

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AB - Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis (P = 3.7 × 10

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DO - 10.1093/hmg/ddu516

M3 - Article

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VL - 24

SP - 1185

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JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 4

ER -

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

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