Genome-wide meta-analysis identifies new susceptibility loci for migraine

V. Anttila, B.S. Winsvold, P. Gormley, T. Kurth, F. Bettella, G. McMahon, M. Kallela, R. Malik, B. de Vries, G. Terwindt, S.E. Medland, U. Todt, W.L. McArdle, L. Quaye, M. Koiranen, M.A. Ikram, T. Lehtimäki, A.H. Stam, L. Ligthart, J. WedenojaI. Dunham, B. M. Neale, P. Palta, E. Hamalainen, M. Schürks, L.M. Rose, J.E. Buring, P.M. Ridker, S. Steinberg, H. Stefansson, F. Jakobsson, D.A. Lawlor, D.M. Evans, S.M. Ring, M. Färkkilä, V. Artto, M.A. Kaunisto, T. Freilinger, J. Schoenen, R.R. Frants, N. Pelzer, C.M. Weller, R. Zielman, A.C. Heath, P.A.F. Madden, G.W. Montgomery, N.G. Martin, G. Borck, H. Göbel, A. Heinze, K. Heinze-Kuhn, F.M. Williams, A.-L. Hartikainen, A. Pouta, J.. van den Ende, A.G. Uitterlinden, A. Hofman, N. Amin, J.J. Hottenga, J.M. Vink, K. Heikkilä, M. Alexander, B. Muller-Myhsok, S Schreiber, T. Meitinger, H. E. Wichmann, A. Aromaa, J.G. Eriksson, B.J. Traynor, D. Trabzuni, E. Rossin, K. Lage, S.B. Jacobs, J.R. Gibbs, E. Birney, J. Kaprio, B.W.J.H. Penninx, D.I. Boomsma, C.M. van Duijn, O. Raitakari, M.-R. Jarvelin, J.A. Zwart, L. Cherkas, D.P. Strachan, C. Kubisch, M.D. Ferrari, A.M.J.M. van den Maagdenberg, M. Dichgans, M. Wessman, G.D. Smith, K. Stefansson, M.J. Daly, DR Nyholt, D.I. Chasman, A. Palotie

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10
Original languageEnglish
Pages (from-to)912-917
JournalNature Genetics
Volume45
Issue number8
Early online date23 Jun 2013
DOIs
Publication statusPublished - 2013

    Fingerprint

Cite this

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., ... Palotie, A. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8), 912-917. https://doi.org/10.1038/ng.2676