Genome-wide meta-analysis identifies new susceptibility loci for migraine

V. Anttila; B.S. Winsvold; P. Gormley; T. Kurth; F. Bettella; G. McMahon; M. Kallela; R. Malik; B. de Vries; G. Terwindt; S.E. Medland; U. Todt; W.L. McArdle; L. Quaye; M. Koiranen; M.A. Ikram; T. Lehtimäki; A.H. Stam; L. Ligthart; J. Wedenoja; I. Dunham; B. M. Neale; P. Palta; E. Hamalainen; M. Schürks; L.M. Rose; J.E. Buring; P.M. Ridker; S. Steinberg; H. Stefansson; F. Jakobsson; D.A. Lawlor; D.M. Evans; S.M. Ring; M. Färkkilä; V. Artto; M.A. Kaunisto; T. Freilinger; J. Schoenen; R.R. Frants; N. Pelzer; C.M. Weller; R. Zielman; A.C. Heath; P.A.F. Madden; G.W. Montgomery; N.G. Martin; G. Borck; H. Göbel; A. Heinze; K. Heinze-Kuhn; F.M. Williams; A.-L. Hartikainen; A. Pouta; J.. van den Ende; A.G. Uitterlinden; A. Hofman; N. Amin; J.J. Hottenga; J.M. Vink; K. Heikkilä; M. Alexander; B. Muller-Myhsok; S Schreiber; T. Meitinger; H. E. Wichmann; A. Aromaa; J.G. Eriksson; B.J. Traynor; D. Trabzuni; E. Rossin; K. Lage; S.B. Jacobs; J.R. Gibbs; E. Birney; J. Kaprio; B.W.J.H. Penninx; D.I. Boomsma; C.M. van Duijn; O. Raitakari; M.-R. Jarvelin; J.A. Zwart; L. Cherkas; D.P. Strachan; C. Kubisch; M.D. Ferrari; A.M.J.M. van den Maagdenberg; M. Dichgans; M. Wessman; G.D. Smith; K. Stefansson; M.J. Daly; DR Nyholt; D.I. Chasman; A. Palotie

doi:10.1038/ng.2676

Genome-wide meta-analysis identifies new susceptibility loci for migraine

V. Anttila, B.S. Winsvold, P. Gormley, T. Kurth, F. Bettella, G. McMahon, M. Kallela, R. Malik, B. de Vries, G. Terwindt, S.E. Medland, U. Todt, W.L. McArdle, L. Quaye, M. Koiranen, M.A. Ikram, T. Lehtimäki, A.H. Stam, L. Ligthart, J. WedenojaI. Dunham, B. M. Neale, P. Palta, E. Hamalainen, M. Schürks, L.M. Rose, J.E. Buring, P.M. Ridker, S. Steinberg, H. Stefansson, F. Jakobsson, D.A. Lawlor, D.M. Evans, S.M. Ring, M. Färkkilä, V. Artto, M.A. Kaunisto, T. Freilinger, J. Schoenen, R.R. Frants, N. Pelzer, C.M. Weller, R. Zielman, A.C. Heath, P.A.F. Madden, G.W. Montgomery, N.G. Martin, G. Borck, H. Göbel, A. Heinze, K. Heinze-Kuhn, F.M. Williams, A.-L. Hartikainen, A. Pouta, J.. van den Ende, A.G. Uitterlinden, A. Hofman, N. Amin, J.J. Hottenga, J.M. Vink, K. Heikkilä, M. Alexander, B. Muller-Myhsok, S Schreiber, T. Meitinger, H. E. Wichmann, A. Aromaa, J.G. Eriksson, B.J. Traynor, D. Trabzuni, E. Rossin, K. Lage, S.B. Jacobs, J.R. Gibbs, E. Birney, J. Kaprio, B.W.J.H. Penninx, D.I. Boomsma, C.M. van Duijn, O. Raitakari, M.-R. Jarvelin, J.A. Zwart, L. Cherkas, D.P. Strachan, C. Kubisch, M.D. Ferrari, A.M.J.M. van den Maagdenberg, M. Dichgans, M. Wessman, G.D. Smith, K. Stefansson, M.J. Daly, DR Nyholt, D.I. Chasman, A. Palotie

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Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10

Original language	English
Pages (from-to)	912-917
Journal	Nature Genetics
Volume	45
Issue number	8
Early online date	23 Jun 2013
DOIs	https://doi.org/10.1038/ng.2676
Publication status	Published - 2013

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Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., ... Palotie, A. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8), 912-917. https://doi.org/10.1038/ng.2676

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title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine",

abstract = "Migraine is the most common brain disorder, affecting approximately 14\% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10",

author = "V. Anttila and B.S. Winsvold and P. Gormley and T. Kurth and F. Bettella and G. McMahon and M. Kallela and R. Malik and \{de Vries\}, B. and G. Terwindt and S.E. Medland and U. Todt and W.L. McArdle and L. Quaye and M. Koiranen and M.A. Ikram and T. Lehtim{\"a}ki and A.H. Stam and L. Ligthart and J. Wedenoja and I. Dunham and Neale, \{B. M.\} and P. Palta and E. Hamalainen and M. Sch{\"u}rks and L.M. Rose and J.E. Buring and P.M. Ridker and S. Steinberg and H. Stefansson and F. Jakobsson and D.A. Lawlor and D.M. Evans and S.M. Ring and M. F{\"a}rkkil{\"a} and V. Artto and M.A. Kaunisto and T. Freilinger and J. Schoenen and R.R. Frants and N. Pelzer and C.M. Weller and R. Zielman and A.C. Heath and P.A.F. Madden and G.W. Montgomery and N.G. Martin and G. Borck and H. G{\"o}bel and A. Heinze and K. Heinze-Kuhn and F.M. Williams and A.-L. Hartikainen and A. Pouta and \{van den Ende\}, J.. and A.G. Uitterlinden and A. Hofman and N. Amin and J.J. Hottenga and J.M. Vink and K. Heikkil{\"a} and M. Alexander and B. Muller-Myhsok and S Schreiber and T. Meitinger and Wichmann, \{H. E.\} and A. Aromaa and J.G. Eriksson and B.J. Traynor and D. Trabzuni and E. Rossin and K. Lage and S.B. Jacobs and J.R. Gibbs and E. Birney and J. Kaprio and B.W.J.H. Penninx and D.I. Boomsma and \{van Duijn\}, C.M. and O. Raitakari and M.-R. Jarvelin and J.A. Zwart and L. Cherkas and D.P. Strachan and C. Kubisch and M.D. Ferrari and \{van den Maagdenberg\}, A.M.J.M. and M. Dichgans and M. Wessman and G.D. Smith and K. Stefansson and M.J. Daly and DR Nyholt and D.I. Chasman and A. Palotie",

year = "2013",

doi = "10.1038/ng.2676",

language = "English",

volume = "45",

pages = "912--917",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "8",

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Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, de Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, MA, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Göbel, H, Heinze, A, Heinze-Kuhn, K, Williams, FM, Hartikainen, A-L, Pouta, A, van den Ende, J, Uitterlinden, AG, Hofman, A, Amin, N, Hottenga, JJ, Vink, JM, Heikkilä, K, Alexander, M, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Wichmann, HE, Aromaa, A, Eriksson, JG, Traynor, BJ, Trabzuni, D, Rossin, E, Lage, K, Jacobs, SB, Gibbs, JR, Birney, E, Kaprio, J, Penninx, BWJH, Boomsma, DI, van Duijn, CM, Raitakari, O, Jarvelin, M-R, Zwart, JA, Cherkas, L, Strachan, DP, Kubisch, C, Ferrari, MD, van den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Daly, MJ, Nyholt, DR, Chasman, DI & Palotie, A 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine', Nature Genetics, vol. 45, no. 8, pp. 912-917. https://doi.org/10.1038/ng.2676

TY - JOUR

T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine

AU - Anttila, V.

AU - Winsvold, B.S.

AU - Gormley, P.

AU - Kurth, T.

AU - Bettella, F.

AU - McMahon, G.

AU - Kallela, M.

AU - Malik, R.

AU - de Vries, B.

AU - Terwindt, G.

AU - Medland, S.E.

AU - Todt, U.

AU - McArdle, W.L.

AU - Quaye, L.

AU - Koiranen, M.

AU - Ikram, M.A.

AU - Lehtimäki, T.

AU - Stam, A.H.

AU - Ligthart, L.

AU - Wedenoja, J.

AU - Dunham, I.

AU - Neale, B. M.

AU - Palta, P.

AU - Hamalainen, E.

AU - Schürks, M.

AU - Rose, L.M.

AU - Buring, J.E.

AU - Ridker, P.M.

AU - Steinberg, S.

AU - Stefansson, H.

AU - Jakobsson, F.

AU - Lawlor, D.A.

AU - Evans, D.M.

AU - Ring, S.M.

AU - Färkkilä, M.

AU - Artto, V.

AU - Kaunisto, M.A.

AU - Freilinger, T.

AU - Schoenen, J.

AU - Frants, R.R.

AU - Pelzer, N.

AU - Weller, C.M.

AU - Zielman, R.

AU - Heath, A.C.

AU - Madden, P.A.F.

AU - Montgomery, G.W.

AU - Martin, N.G.

AU - Borck, G.

AU - Göbel, H.

AU - Heinze, A.

AU - Heinze-Kuhn, K.

AU - Williams, F.M.

AU - Hartikainen, A.-L.

AU - Pouta, A.

AU - van den Ende, J..

AU - Uitterlinden, A.G.

AU - Hofman, A.

AU - Amin, N.

AU - Hottenga, J.J.

AU - Vink, J.M.

AU - Heikkilä, K.

AU - Alexander, M.

AU - Muller-Myhsok, B.

AU - Schreiber, S

AU - Meitinger, T.

AU - Wichmann, H. E.

AU - Aromaa, A.

AU - Eriksson, J.G.

AU - Traynor, B.J.

AU - Trabzuni, D.

AU - Rossin, E.

AU - Lage, K.

AU - Jacobs, S.B.

AU - Gibbs, J.R.

AU - Birney, E.

AU - Kaprio, J.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

AU - van Duijn, C.M.

AU - Raitakari, O.

AU - Jarvelin, M.-R.

AU - Zwart, J.A.

AU - Cherkas, L.

AU - Strachan, D.P.

AU - Kubisch, C.

AU - Ferrari, M.D.

AU - van den Maagdenberg, A.M.J.M.

AU - Dichgans, M.

AU - Wessman, M.

AU - Smith, G.D.

AU - Stefansson, K.

AU - Daly, M.J.

AU - Nyholt, DR

AU - Chasman, D.I.

AU - Palotie, A.

PY - 2013

Y1 - 2013

N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10

AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10

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UR - https://www.scopus.com/inward/citedby.url?scp=84881022482&partnerID=8YFLogxK

U2 - 10.1038/ng.2676

DO - 10.1038/ng.2676

M3 - Article

SN - 1061-4036

VL - 45

SP - 912

EP - 917

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide meta-analysis identifies new susceptibility loci for migraine

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