Genome-wide meta-analysis of cognitive empathy: Heritability, and correlates with sex, neuropsychiatric conditions and cognition

V. Warrier; K. L. Grasby; F. Uzefovsky; R. Toro; P. Smith; B. Chakrabarti; J. Khadake; E. Mawbey-Adamson; N. Litterman; J. J. Hottenga; G. Lubke; D. I. Boomsma; N. G. Martin; P. K. Hatemi; S. E. Medland; D. A. Hinds; T. Bourgeron; S. Baron-Cohen

doi:10.1038/mp.2017.122

Genome-wide meta-analysis of cognitive empathy: Heritability, and correlates with sex, neuropsychiatric conditions and cognition

V. Warrier^*, K. L. Grasby, F. Uzefovsky, R. Toro, P. Smith, B. Chakrabarti, J. Khadake, E. Mawbey-Adamson, N. Litterman, J. J. Hottenga, G. Lubke, D. I. Boomsma, N. G. Martin, P. K. Hatemi, S. E. Medland, D. A. Hinds, T. Bourgeron, S. Baron-Cohen

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10 ^-16), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, P meta =1.58 × 10 ^-8). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10 ^-17) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.

Original language	English
Pages (from-to)	1402-1409
Number of pages	8
Journal	Molecular Psychiatry
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/mp.2017.122
Publication status	Published - 6 Jun 2018

Keywords

Journal Article

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Warrier, V., Grasby, K. L., Uzefovsky, F., Toro, R., Smith, P., Chakrabarti, B., Khadake, J., Mawbey-Adamson, E., Litterman, N., Hottenga, J. J., Lubke, G., Boomsma, D. I., Martin, N. G., Hatemi, P. K., Medland, S. E., Hinds, D. A., Bourgeron, T., & Baron-Cohen, S. (2018). Genome-wide meta-analysis of cognitive empathy: Heritability, and correlates with sex, neuropsychiatric conditions and cognition. Molecular Psychiatry, 23(6), 1402-1409. https://doi.org/10.1038/mp.2017.122

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abstract = "We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10 -16), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, P meta =1.58 × 10 -8). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10 -17) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.",

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Warrier, V, Grasby, KL, Uzefovsky, F, Toro, R, Smith, P, Chakrabarti, B, Khadake, J, Mawbey-Adamson, E, Litterman, N, Hottenga, JJ, Lubke, G, Boomsma, DI, Martin, NG, Hatemi, PK, Medland, SE, Hinds, DA, Bourgeron, T & Baron-Cohen, S 2018, 'Genome-wide meta-analysis of cognitive empathy: Heritability, and correlates with sex, neuropsychiatric conditions and cognition', Molecular Psychiatry, vol. 23, no. 6, pp. 1402-1409. https://doi.org/10.1038/mp.2017.122

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AU - Smith, P.

AU - Chakrabarti, B.

AU - Khadake, J.

AU - Mawbey-Adamson, E.

AU - Litterman, N.

AU - Hottenga, J. J.

AU - Lubke, G.

AU - Boomsma, D. I.

AU - Martin, N. G.

AU - Hatemi, P. K.

AU - Medland, S. E.

AU - Hinds, D. A.

AU - Bourgeron, T.

AU - Baron-Cohen, S.

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Genome-wide meta-analysis of cognitive empathy: Heritability, and correlates with sex, neuropsychiatric conditions and cognition

Abstract

Keywords

Cohort Studies

UN SDGs

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