Genome-wide meta-analysis of common variant differences between men and women

V. Boraska; A. Jeroncic; V. Colonna; L. Southam; DR Nyholt; N.W. Rayner; J.R.B. Perry; D. Toniolo; E. Albrecht; W. Ang; S. Bandinelli; M. Barbalic; I. Barroso; J.S. Beckmann; R. Biffar; D.I. Boomsma; H. Campbell; T. Corre; J. Erdmann; T. Esko; K. Fischer; N. Franceschini; T.M. Frayling; G. Girotto; J.R. Gonzalez; T.B. Harris; A.C. Heath; I.M. Heid; W. Hoffmann; A. Hofman; M. Horikoshi; J.H. Zhao; A.U. Jackson; J.J. Hottenga; A. Jula; M. Kähönen; K.T. Khaw; L.A. Kiemeney; N. Klopp; Z. Kutalik; V. Lagou; L.J. Launer; T. Lehtimäki; M. Lemire; M.L. Lokki; C. Loley; J.A. Luan; M. Mangino; I. Mateo Leach; S.E. Medland; E. Mihailov; G.W. Montgomery; G. Navis; J. Newnham; M.S. Nieminen; A. Palotie; K. Panoutsopoulou; A. Peters; N. Pirastu; O. Polasek; K. Rehnström; S. Ripatti; G.R.S. Ritchie; F. Rivadeneira; A. Robino; N.J. Samani; S.Y. Shin; J. Sinisalo; J.H. Smit; N. Soranzo; L. Stolk; D.W. Swinkels; T. Tanaka; A. Teumer; A. Tönjes; M. Traglia; J. Tuomilehto; A. Valsesia; W.H. van Gilst; J.B.J. van Meurs; A. Vernon Smith; J. Viikari; J.M. Vink; G. Waeber; N.M. Warrington; E. Widen; G. Willemsen; A.F. Wright; B.W. Zanke; L. Zgaga; M. Boehnke; A. Pio d'Adamo; E.J.C. de Geus; E.W. Demerath; M. den Heijer; J.G. Eriksson; L. Ferrucci; C. Gieger; V. Gudnason; C. Hayward; C. Hengstenberg; T.J. Hudson; M.J. Järvelin; M. Kogevinas; R.J.F. Loos; N.G. Martin; A. Metspalu; C.E. Pennell; B.W.J.H. Penninx; M. Perola; O. Raitakari; V. Salomaa; S Schreiber; H. Schunkert; T.D. Spector; M. Stumvoll; A.G. Uitterlinden; S. Ulivi; P. van der Harst; P. Vollenweider; H. Völzke; N.J. Wareham; H.E. Wichmann; J.F. Wilson; I. Rudan; Y Xue; E. Zeggini

doi:10.1093/hmg/dds304

Genome-wide meta-analysis of common variant differences between men and women

V. Boraska, A. Jeroncic, V. Colonna, L. Southam, DR Nyholt, N.W. Rayner, J.R.B. Perry, D. Toniolo, E. Albrecht, W. Ang, S. Bandinelli, M. Barbalic, I. Barroso, J.S. Beckmann, R. Biffar, D.I. Boomsma, H. Campbell, T. Corre, J. Erdmann, T. EskoK. Fischer, N. Franceschini, T.M. Frayling, G. Girotto, J.R. Gonzalez, T.B. Harris, A.C. Heath, I.M. Heid, W. Hoffmann, A. Hofman, M. Horikoshi, J.H. Zhao, A.U. Jackson, J.J. Hottenga, A. Jula, M. Kähönen, K.T. Khaw, L.A. Kiemeney, N. Klopp, Z. Kutalik, V. Lagou, L.J. Launer, T. Lehtimäki, M. Lemire, M.L. Lokki, C. Loley, J.A. Luan, M. Mangino, I. Mateo Leach, S.E. Medland, E. Mihailov, G.W. Montgomery, G. Navis, J. Newnham, M.S. Nieminen, A. Palotie, K. Panoutsopoulou, A. Peters, N. Pirastu, O. Polasek, K. Rehnström, S. Ripatti, G.R.S. Ritchie, F. Rivadeneira, A. Robino, N.J. Samani, S.Y. Shin, J. Sinisalo, J.H. Smit, N. Soranzo, L. Stolk, D.W. Swinkels, T. Tanaka, A. Teumer, A. Tönjes, M. Traglia, J. Tuomilehto, A. Valsesia, W.H. van Gilst, J.B.J. van Meurs, A. Vernon Smith, J. Viikari, J.M. Vink, G. Waeber, N.M. Warrington, E. Widen, G. Willemsen, A.F. Wright, B.W. Zanke, L. Zgaga, M. Boehnke, A. Pio d'Adamo, E.J.C. de Geus, E.W. Demerath, M. den Heijer, J.G. Eriksson, L. Ferrucci, C. Gieger, V. Gudnason, C. Hayward, C. Hengstenberg, T.J. Hudson, M.J. Järvelin, M. Kogevinas, R.J.F. Loos, N.G. Martin, A. Metspalu, C.E. Pennell, B.W.J.H. Penninx, M. Perola, O. Raitakari, V. Salomaa, S Schreiber, H. Schunkert, T.D. Spector, M. Stumvoll, A.G. Uitterlinden, S. Ulivi, P. van der Harst, P. Vollenweider, H. Völzke, N.J. Wareham, H.E. Wichmann, J.F. Wilson, I. Rudan, Y Xue, E. Zeggini

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10

Original language	English
Pages (from-to)	4805-4815
Journal	Human Molecular Genetics
Volume	21
Issue number	21
DOIs	https://doi.org/10.1093/hmg/dds304
Publication status	Published - 2012

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Boraska, V., Jeroncic, A., Colonna, V., Southam, L., Nyholt, DR., Rayner, N. W., Perry, J. R. B., Toniolo, D., Albrecht, E., Ang, W., Bandinelli, S., Barbalic, M., Barroso, I., Beckmann, J. S., Biffar, R., Boomsma, D. I., Campbell, H., Corre, T., Erdmann, J., ... Zeggini, E. (2012). Genome-wide meta-analysis of common variant differences between men and women. Human Molecular Genetics, 21(21), 4805-4815. https://doi.org/10.1093/hmg/dds304

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title = "Genome-wide meta-analysis of common variant differences between men and women",

abstract = "The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10",

author = "V. Boraska and A. Jeroncic and V. Colonna and L. Southam and DR Nyholt and N.W. Rayner and J.R.B. Perry and D. Toniolo and E. Albrecht and W. Ang and S. Bandinelli and M. Barbalic and I. Barroso and J.S. Beckmann and R. Biffar and D.I. Boomsma and H. Campbell and T. Corre and J. Erdmann and T. Esko and K. Fischer and N. Franceschini and T.M. Frayling and G. Girotto and J.R. Gonzalez and T.B. Harris and A.C. Heath and I.M. Heid and W. Hoffmann and A. Hofman and M. Horikoshi and J.H. Zhao and A.U. Jackson and J.J. Hottenga and A. Jula and M. K{\"a}h{\"o}nen and K.T. Khaw and L.A. Kiemeney and N. Klopp and Z. Kutalik and V. Lagou and L.J. Launer and T. Lehtim{\"a}ki and M. Lemire and M.L. Lokki and C. Loley and J.A. Luan and M. Mangino and {Mateo Leach}, I. and S.E. Medland and E. Mihailov and G.W. Montgomery and G. Navis and J. Newnham and M.S. Nieminen and A. Palotie and K. Panoutsopoulou and A. Peters and N. Pirastu and O. Polasek and K. Rehnstr{\"o}m and S. Ripatti and G.R.S. Ritchie and F. Rivadeneira and A. Robino and N.J. Samani and S.Y. Shin and J. Sinisalo and J.H. Smit and N. Soranzo and L. Stolk and D.W. Swinkels and T. Tanaka and A. Teumer and A. T{\"o}njes and M. Traglia and J. Tuomilehto and A. Valsesia and {van Gilst}, W.H. and {van Meurs}, J.B.J. and {Vernon Smith}, A. and J. Viikari and J.M. Vink and G. Waeber and N.M. Warrington and E. Widen and G. Willemsen and A.F. Wright and B.W. Zanke and L. Zgaga and M. Boehnke and {Pio d'Adamo}, A. and {de Geus}, E.J.C. and E.W. Demerath and {den Heijer}, M. and J.G. Eriksson and L. Ferrucci and C. Gieger and V. Gudnason and C. Hayward and C. Hengstenberg and T.J. Hudson and M.J. J{\"a}rvelin and M. Kogevinas and R.J.F. Loos and N.G. Martin and A. Metspalu and C.E. Pennell and B.W.J.H. Penninx and M. Perola and O. Raitakari and V. Salomaa and S Schreiber and H. Schunkert and T.D. Spector and M. Stumvoll and A.G. Uitterlinden and S. Ulivi and {van der Harst}, P. and P. Vollenweider and H. V{\"o}lzke and N.J. Wareham and H.E. Wichmann and J.F. Wilson and I. Rudan and Y Xue and E. Zeggini",

year = "2012",

doi = "10.1093/hmg/dds304",

language = "English",

volume = "21",

pages = "4805--4815",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "21",

}

Boraska, V, Jeroncic, A, Colonna, V, Southam, L, Nyholt, DR, Rayner, NW, Perry, JRB, Toniolo, D, Albrecht, E, Ang, W, Bandinelli, S, Barbalic, M, Barroso, I, Beckmann, JS, Biffar, R, Boomsma, DI, Campbell, H, Corre, T, Erdmann, J, Esko, T, Fischer, K, Franceschini, N, Frayling, TM, Girotto, G, Gonzalez, JR, Harris, TB, Heath, AC, Heid, IM, Hoffmann, W, Hofman, A, Horikoshi, M, Zhao, JH, Jackson, AU, Hottenga, JJ, Jula, A, Kähönen, M, Khaw, KT, Kiemeney, LA, Klopp, N, Kutalik, Z, Lagou, V, Launer, LJ, Lehtimäki, T, Lemire, M, Lokki, ML, Loley, C, Luan, JA, Mangino, M, Mateo Leach, I, Medland, SE, Mihailov, E, Montgomery, GW, Navis, G, Newnham, J, Nieminen, MS, Palotie, A, Panoutsopoulou, K, Peters, A, Pirastu, N, Polasek, O, Rehnström, K, Ripatti, S, Ritchie, GRS, Rivadeneira, F, Robino, A, Samani, NJ, Shin, SY, Sinisalo, J, Smit, JH, Soranzo, N, Stolk, L, Swinkels, DW, Tanaka, T, Teumer, A, Tönjes, A, Traglia, M, Tuomilehto, J, Valsesia, A, van Gilst, WH, van Meurs, JBJ, Vernon Smith, A, Viikari, J, Vink, JM, Waeber, G, Warrington, NM, Widen, E, Willemsen, G, Wright, AF, Zanke, BW, Zgaga, L, Boehnke, M, Pio d'Adamo, A, de Geus, EJC, Demerath, EW, den Heijer, M, Eriksson, JG, Ferrucci, L, Gieger, C, Gudnason, V, Hayward, C, Hengstenberg, C, Hudson, TJ, Järvelin, MJ, Kogevinas, M, Loos, RJF, Martin, NG, Metspalu, A, Pennell, CE, Penninx, BWJH, Perola, M, Raitakari, O, Salomaa, V, Schreiber, S, Schunkert, H, Spector, TD, Stumvoll, M, Uitterlinden, AG, Ulivi, S, van der Harst, P, Vollenweider, P, Völzke, H, Wareham, NJ, Wichmann, HE, Wilson, JF, Rudan, I, Xue, Y & Zeggini, E 2012, 'Genome-wide meta-analysis of common variant differences between men and women', Human Molecular Genetics, vol. 21, no. 21, pp. 4805-4815. https://doi.org/10.1093/hmg/dds304

TY - JOUR

T1 - Genome-wide meta-analysis of common variant differences between men and women

AU - Boraska, V.

AU - Jeroncic, A.

AU - Colonna, V.

AU - Southam, L.

AU - Nyholt, DR

AU - Rayner, N.W.

AU - Perry, J.R.B.

AU - Toniolo, D.

AU - Albrecht, E.

AU - Ang, W.

AU - Bandinelli, S.

AU - Barbalic, M.

AU - Barroso, I.

AU - Beckmann, J.S.

AU - Biffar, R.

AU - Boomsma, D.I.

AU - Campbell, H.

AU - Corre, T.

AU - Erdmann, J.

AU - Esko, T.

AU - Fischer, K.

AU - Franceschini, N.

AU - Frayling, T.M.

AU - Girotto, G.

AU - Gonzalez, J.R.

AU - Harris, T.B.

AU - Heath, A.C.

AU - Heid, I.M.

AU - Hoffmann, W.

AU - Hofman, A.

AU - Horikoshi, M.

AU - Zhao, J.H.

AU - Jackson, A.U.

AU - Hottenga, J.J.

AU - Jula, A.

AU - Kähönen, M.

AU - Khaw, K.T.

AU - Kiemeney, L.A.

AU - Klopp, N.

AU - Kutalik, Z.

AU - Lagou, V.

AU - Launer, L.J.

AU - Lehtimäki, T.

AU - Lemire, M.

AU - Lokki, M.L.

AU - Loley, C.

AU - Luan, J.A.

AU - Mangino, M.

AU - Mateo Leach, I.

AU - Medland, S.E.

AU - Mihailov, E.

AU - Montgomery, G.W.

AU - Navis, G.

AU - Newnham, J.

AU - Nieminen, M.S.

AU - Palotie, A.

AU - Panoutsopoulou, K.

AU - Peters, A.

AU - Pirastu, N.

AU - Polasek, O.

AU - Rehnström, K.

AU - Ripatti, S.

AU - Ritchie, G.R.S.

AU - Rivadeneira, F.

AU - Robino, A.

AU - Samani, N.J.

AU - Shin, S.Y.

AU - Sinisalo, J.

AU - Smit, J.H.

AU - Soranzo, N.

AU - Stolk, L.

AU - Swinkels, D.W.

AU - Tanaka, T.

AU - Teumer, A.

AU - Tönjes, A.

AU - Traglia, M.

AU - Tuomilehto, J.

AU - Valsesia, A.

AU - van Gilst, W.H.

AU - van Meurs, J.B.J.

AU - Vernon Smith, A.

AU - Viikari, J.

AU - Vink, J.M.

AU - Waeber, G.

AU - Warrington, N.M.

AU - Widen, E.

AU - Willemsen, G.

AU - Wright, A.F.

AU - Zanke, B.W.

AU - Zgaga, L.

AU - Boehnke, M.

AU - Pio d'Adamo, A.

AU - de Geus, E.J.C.

AU - Demerath, E.W.

AU - den Heijer, M.

AU - Eriksson, J.G.

AU - Ferrucci, L.

AU - Gieger, C.

AU - Gudnason, V.

AU - Hayward, C.

AU - Hengstenberg, C.

AU - Hudson, T.J.

AU - Järvelin, M.J.

AU - Kogevinas, M.

AU - Loos, R.J.F.

AU - Martin, N.G.

AU - Metspalu, A.

AU - Pennell, C.E.

AU - Penninx, B.W.J.H.

AU - Perola, M.

AU - Raitakari, O.

AU - Salomaa, V.

AU - Schreiber, S

AU - Schunkert, H.

AU - Spector, T.D.

AU - Stumvoll, M.

AU - Uitterlinden, A.G.

AU - Ulivi, S.

AU - van der Harst, P.

AU - Vollenweider, P.

AU - Völzke, H.

AU - Wareham, N.J.

AU - Wichmann, H.E.

AU - Wilson, J.F.

AU - Rudan, I.

AU - Xue, Y

AU - Zeggini, E.

PY - 2012

Y1 - 2012

N2 - The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10

AB - The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10

U2 - 10.1093/hmg/dds304

DO - 10.1093/hmg/dds304

M3 - Article

SN - 0964-6906

VL - 21

SP - 4805

EP - 4815

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 21

ER -

Genome-wide meta-analysis of common variant differences between men and women

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