Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q and 17P.

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Large-scale studies estimate the heritability of blood pressure at ≈50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation. © 2007 American Heart Association, Inc.
Original languageEnglish
Pages (from-to)832-838
JournalHypertension
Volume49
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Genome
Blood Pressure
Chromosomes
Dizygotic Twins
Netherlands
Microsatellite Repeats
Siblings
Multivariate Analysis
Parents

Cite this

@article{0bc1a7988883428599f3f3ae2329e133,
title = "Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q and 17P.",
abstract = "Large-scale studies estimate the heritability of blood pressure at ≈50{\%}. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation. {\circledC} 2007 American Heart Association, Inc.",
author = "J.J. Hottenga and J.B. Whitfield and D. Posthuma and A.H.M. Willemsen and {de Geus}, E.J.C. and N.G. Martin and D.I. Boomsma",
year = "2007",
doi = "10.1161/01.HYP.0000260092.93964.ed",
language = "English",
volume = "49",
pages = "832--838",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q and 17P. / Hottenga, J.J.; Whitfield, J.B.; Posthuma, D.; Willemsen, A.H.M.; de Geus, E.J.C.; Martin, N.G.; Boomsma, D.I.

In: Hypertension, Vol. 49, No. 4, 2007, p. 832-838.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q and 17P.

AU - Hottenga, J.J.

AU - Whitfield, J.B.

AU - Posthuma, D.

AU - Willemsen, A.H.M.

AU - de Geus, E.J.C.

AU - Martin, N.G.

AU - Boomsma, D.I.

PY - 2007

Y1 - 2007

N2 - Large-scale studies estimate the heritability of blood pressure at ≈50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation. © 2007 American Heart Association, Inc.

AB - Large-scale studies estimate the heritability of blood pressure at ≈50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation. © 2007 American Heart Association, Inc.

U2 - 10.1161/01.HYP.0000260092.93964.ed

DO - 10.1161/01.HYP.0000260092.93964.ed

M3 - Article

VL - 49

SP - 832

EP - 838

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -