Geographical structure and differential natural selection amongst North European populations

B.P. McEvoy; GW Montgomery; A.F. McRae; S. Ripatti; M. Perola; T.D. Spector; L.F. Cherkas; K. Ahmadi; D.I. Boomsma; G. Willemsen; J.J. Hottenga; N.L. Pedersen; P.K.E. Magnusson; K. Kyvik; K. Christensen; J. Kaprio; K. Heikkilä; A. Palotie; E. Widen; J. Muilu; A.C. Syvänen; U. Liljedahl; O. Hardiman; S. Cronin; L. Peltonen; N.G. Martin; P.M. Visscher

doi:10.1101/gr.083394.108

Geographical structure and differential natural selection amongst North European populations

B.P. McEvoy, GW Montgomery, A.F. McRae, S. Ripatti, M. Perola, T.D. Spector, L.F. Cherkas, K. Ahmadi, D.I. Boomsma, G. Willemsen, J.J. Hottenga, N.L. Pedersen, P.K.E. Magnusson, K. Kyvik, K. Christensen, J. Kaprio, K. Heikkilä, A. Palotie, E. Widen, J. MuiluA.C. Syvänen, U. Liljedahl, O. Hardiman, S. Cronin, L. Peltonen, N.G. Martin, P.M. Visscher

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Abstract

Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F

Original language	English
Pages (from-to)	804-814
Journal	Genome Research
Volume	19
Issue number	5
DOIs	https://doi.org/10.1101/gr.083394.108
Publication status	Published - 2009

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McEvoy GR 2009

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2009/McEvoy_GR_2009.pdf

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McEvoy, B. P., Montgomery, GW., McRae, A. F., Ripatti, S., Perola, M., Spector, T. D., Cherkas, L. F., Ahmadi, K., Boomsma, D. I., Willemsen, G., Hottenga, J. J., Pedersen, N. L., Magnusson, P. K. E., Kyvik, K., Christensen, K., Kaprio, J., Heikkilä, K., Palotie, A., Widen, E., ... Visscher, P. M. (2009). Geographical structure and differential natural selection amongst North European populations. Genome Research, 19(5), 804-814. https://doi.org/10.1101/gr.083394.108

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title = "Geographical structure and differential natural selection amongst North European populations",

abstract = "Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F",

author = "B.P. McEvoy and GW Montgomery and A.F. McRae and S. Ripatti and M. Perola and T.D. Spector and L.F. Cherkas and K. Ahmadi and D.I. Boomsma and G. Willemsen and J.J. Hottenga and N.L. Pedersen and P.K.E. Magnusson and K. Kyvik and K. Christensen and J. Kaprio and K. Heikkil{\"a} and A. Palotie and E. Widen and J. Muilu and A.C. Syv{\"a}nen and U. Liljedahl and O. Hardiman and S. Cronin and L. Peltonen and N.G. Martin and P.M. Visscher",

year = "2009",

doi = "10.1101/gr.083394.108",

language = "English",

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pages = "804--814",

journal = "Genome Research",

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McEvoy, BP, Montgomery, GW, McRae, AF, Ripatti, S, Perola, M, Spector, TD, Cherkas, LF, Ahmadi, K, Boomsma, DI , Willemsen, G , Hottenga, JJ, Pedersen, NL, Magnusson, PKE, Kyvik, K, Christensen, K, Kaprio, J, Heikkilä, K, Palotie, A, Widen, E, Muilu, J, Syvänen, AC, Liljedahl, U, Hardiman, O, Cronin, S, Peltonen, L, Martin, NG & Visscher, PM 2009, 'Geographical structure and differential natural selection amongst North European populations', Genome Research, vol. 19, no. 5, pp. 804-814. https://doi.org/10.1101/gr.083394.108

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T1 - Geographical structure and differential natural selection amongst North European populations

AU - McEvoy, B.P.

AU - Montgomery, GW

AU - McRae, A.F.

AU - Ripatti, S.

AU - Perola, M.

AU - Spector, T.D.

AU - Cherkas, L.F.

AU - Ahmadi, K.

AU - Boomsma, D.I.

AU - Willemsen, G.

AU - Hottenga, J.J.

AU - Pedersen, N.L.

AU - Magnusson, P.K.E.

AU - Kyvik, K.

AU - Christensen, K.

AU - Kaprio, J.

AU - Heikkilä, K.

AU - Palotie, A.

AU - Widen, E.

AU - Muilu, J.

AU - Syvänen, A.C.

AU - Liljedahl, U.

AU - Hardiman, O.

AU - Cronin, S.

AU - Peltonen, L.

AU - Martin, N.G.

AU - Visscher, P.M.

PY - 2009

Y1 - 2009

N2 - Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F

AB - Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F

U2 - 10.1101/gr.083394.108

DO - 10.1101/gr.083394.108

M3 - Article

SN - 1088-9051

VL - 19

SP - 804

EP - 814

JO - Genome Research

JF - Genome Research

IS - 5

ER -

Geographical structure and differential natural selection amongst North European populations

Abstract

Cohort Studies

UN SDGs

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