Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)

Laure M G Verstraeten; Jos Kreeftmeijer; Janneke P van Wijngaarden; Carel G M Meskers; Andrea B Maier

doi:10.1016/j.apmr.2024.05.021

Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)

Laure M G Verstraeten, Jos Kreeftmeijer, Janneke P van Wijngaarden, Carel G M Meskers, Andrea B Maier

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To determine the prevalence and co-occurrence of common geriatric syndromes in geriatric rehabilitation inpatients.

DESIGN: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR) are observational, longitudinal cohorts.

SETTING: Geriatric rehabilitation.

PARTICIPANTS: Geriatric rehabilitation inpatients (N=1890 and N=200).

INTERVENTIONS: Not applicable.

MAIN OUTCOME MEASURES: Geriatric syndromes included polypharmacy, multimorbidity (Cumulative Illness Rating Scale), cognitive impairment, depression (Hospital Anxiety and Depression Scale/Geriatric Depression Scale), malnutrition (Global Leadership Initiative on Malnutrition), functional limitation (Katz index), falls, physical frailty (Fried), and sarcopenia (European Working Group on Sarcopenia in Older People 2).

RESULTS: Inpatients in RESORT (R) (N=1890, 56% females) had a median age of 83.4 years (interquartile range [IQR], 77.6-88.4) and in EMPOWER-GR (E) (N=200, 57% females) of 79.8 years (IQR, 75.0-85.9). Polypharmacy (R, 82.2%; E, 84.0%), multimorbidity (R, 90.4%; E, 85.5%), functional limitation (R, 96.0%; E, 76.5%), and frailty (R, 91.8%; E, 92.2%) were most prevalent. Most inpatients had ≥5 geriatric syndromes at admission in both cohorts (R, 70.0%; E, 72.4%); few inpatients had only 1 (R, 0.4%; E, 1.5%) or no geriatric syndrome (R, 0.2%; E, 0.0%). Geriatric syndromes did not occur in isolation (without other syndromes), except for multimorbidity (R, 1%; E, 5%), functional limitation (R, 3%; E, 2%), falls (R, 0%; E, 4%), and frailty (R, 2%; E, 5%), which occurred in isolation in some inpatients; sarcopenia did not.

CONCLUSIONS: Geriatric syndromes are highly prevalent at admission to geriatric rehabilitation, with a median of 5 co-occurring syndromes. Implications for diagnosis and intervention potential should be further addressed.

Original language	English
Pages (from-to)	1854-1861
Number of pages	8
Journal	Archives of Physical Medicine and Rehabilitation
Volume	105
Issue number	10
Early online date	6 Jun 2024
DOIs	https://doi.org/10.1016/j.apmr.2024.05.021
Publication status	Published - Oct 2024

Bibliographical note

Funding

Supported by an unrestricted grant of the University of Melbourne received by A.B.M. and the Medical Research Future Fund (MRFF) provided by the Melbourne Academic Centre for Health (MACH). This work is also part of a collaboration project cofunded by the PPP Allowance made available by Health-Holland (grant number TKI-LSHM19069-H049), Top Sector Life Sciences & Health, to stimulate public-private partnerships, and Top Sector Agri & Food (grant number LWV19287). The collaboration project also includes an in-cash and in-kind contribution from Danone Nutricia Research. This work was supported by an unrestricted grant of the University of Melbourne received by Prof. Andrea B. Maier and the Medical Research Future Fund (MRFF) provided by the Melbourne Academic Centre for Health (MACH). This work is also part of a collaboration project co-funded by the PPP Allowance made available by Health\u223CHolland (grant number TKI-LSHM19069-H049 ), Top Sector Life Sciences & Health, to stimulate public-private partnerships, and Top Sector Agri & Food (grant number LWV19287 ). The collaboration project also includes an in-cash and in-kind contribution from Danone Nutricia Research.

Funders	Funder number
University of Melbourne
Danone Nutricia Research
Medical Research Future Fund
Melbourne Academic Centre for Health	TKI-LSHM19069-H049
Top Sector Agri and Food	LWV19287

Keywords

Humans
Female
Male
Aged
Aged, 80 and over
Accidental Falls/statistics & numerical data
Polypharmacy
Geriatric Assessment
Multimorbidity
Malnutrition/epidemiology
Longitudinal Studies
Sarcopenia/epidemiology
Inpatients
Frailty/rehabilitation
Depression/epidemiology
Syndrome
Cognitive Dysfunction/rehabilitation
Prevalence
Muscle Strength

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Verstraeten, L. M. G., Kreeftmeijer, J., van Wijngaarden, J. P., Meskers, C. G. M., & Maier, A. B. (2024). Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR). Archives of Physical Medicine and Rehabilitation, 105(10), 1854-1861. https://doi.org/10.1016/j.apmr.2024.05.021

Verstraeten, Laure M G ; Kreeftmeijer, Jos ; van Wijngaarden, Janneke P et al. / Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients : Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR). In: Archives of Physical Medicine and Rehabilitation. 2024 ; Vol. 105, No. 10. pp. 1854-1861.

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title = "Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)",

abstract = "OBJECTIVE: To determine the prevalence and co-occurrence of common geriatric syndromes in geriatric rehabilitation inpatients.DESIGN: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR) are observational, longitudinal cohorts.SETTING: Geriatric rehabilitation.PARTICIPANTS: Geriatric rehabilitation inpatients (N=1890 and N=200).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Geriatric syndromes included polypharmacy, multimorbidity (Cumulative Illness Rating Scale), cognitive impairment, depression (Hospital Anxiety and Depression Scale/Geriatric Depression Scale), malnutrition (Global Leadership Initiative on Malnutrition), functional limitation (Katz index), falls, physical frailty (Fried), and sarcopenia (European Working Group on Sarcopenia in Older People 2).RESULTS: Inpatients in RESORT (R) (N=1890, 56% females) had a median age of 83.4 years (interquartile range [IQR], 77.6-88.4) and in EMPOWER-GR (E) (N=200, 57% females) of 79.8 years (IQR, 75.0-85.9). Polypharmacy (R, 82.2%; E, 84.0%), multimorbidity (R, 90.4%; E, 85.5%), functional limitation (R, 96.0%; E, 76.5%), and frailty (R, 91.8%; E, 92.2%) were most prevalent. Most inpatients had ≥5 geriatric syndromes at admission in both cohorts (R, 70.0%; E, 72.4%); few inpatients had only 1 (R, 0.4%; E, 1.5%) or no geriatric syndrome (R, 0.2%; E, 0.0%). Geriatric syndromes did not occur in isolation (without other syndromes), except for multimorbidity (R, 1%; E, 5%), functional limitation (R, 3%; E, 2%), falls (R, 0%; E, 4%), and frailty (R, 2%; E, 5%), which occurred in isolation in some inpatients; sarcopenia did not.CONCLUSIONS: Geriatric syndromes are highly prevalent at admission to geriatric rehabilitation, with a median of 5 co-occurring syndromes. Implications for diagnosis and intervention potential should be further addressed.",

keywords = "Humans, Female, Male, Aged, Aged, 80 and over, Accidental Falls/statistics & numerical data, Polypharmacy, Geriatric Assessment, Multimorbidity, Malnutrition/epidemiology, Longitudinal Studies, Sarcopenia/epidemiology, Inpatients, Frailty/rehabilitation, Depression/epidemiology, Syndrome, Cognitive Dysfunction/rehabilitation, Prevalence, Muscle Strength",

author = "Verstraeten, {Laure M G} and Jos Kreeftmeijer and {van Wijngaarden}, {Janneke P} and Meskers, {Carel G M} and Maier, {Andrea B}",

year = "2024",

month = oct,

doi = "10.1016/j.apmr.2024.05.021",

language = "English",

volume = "105",

pages = "1854--1861",

journal = "Archives of Physical Medicine and Rehabilitation",

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Verstraeten, LMG, Kreeftmeijer, J, van Wijngaarden, JP, Meskers, CGM & Maier, AB 2024, 'Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)', Archives of Physical Medicine and Rehabilitation, vol. 105, no. 10, pp. 1854-1861. https://doi.org/10.1016/j.apmr.2024.05.021

Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR). / Verstraeten, Laure M G; Kreeftmeijer, Jos; van Wijngaarden, Janneke P et al.
In: Archives of Physical Medicine and Rehabilitation, Vol. 105, No. 10, 10.2024, p. 1854-1861.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients

T2 - Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)

AU - Verstraeten, Laure M G

AU - Kreeftmeijer, Jos

AU - van Wijngaarden, Janneke P

AU - Meskers, Carel G M

AU - Maier, Andrea B

PY - 2024/10

Y1 - 2024/10

N2 - OBJECTIVE: To determine the prevalence and co-occurrence of common geriatric syndromes in geriatric rehabilitation inpatients.DESIGN: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR) are observational, longitudinal cohorts.SETTING: Geriatric rehabilitation.PARTICIPANTS: Geriatric rehabilitation inpatients (N=1890 and N=200).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Geriatric syndromes included polypharmacy, multimorbidity (Cumulative Illness Rating Scale), cognitive impairment, depression (Hospital Anxiety and Depression Scale/Geriatric Depression Scale), malnutrition (Global Leadership Initiative on Malnutrition), functional limitation (Katz index), falls, physical frailty (Fried), and sarcopenia (European Working Group on Sarcopenia in Older People 2).RESULTS: Inpatients in RESORT (R) (N=1890, 56% females) had a median age of 83.4 years (interquartile range [IQR], 77.6-88.4) and in EMPOWER-GR (E) (N=200, 57% females) of 79.8 years (IQR, 75.0-85.9). Polypharmacy (R, 82.2%; E, 84.0%), multimorbidity (R, 90.4%; E, 85.5%), functional limitation (R, 96.0%; E, 76.5%), and frailty (R, 91.8%; E, 92.2%) were most prevalent. Most inpatients had ≥5 geriatric syndromes at admission in both cohorts (R, 70.0%; E, 72.4%); few inpatients had only 1 (R, 0.4%; E, 1.5%) or no geriatric syndrome (R, 0.2%; E, 0.0%). Geriatric syndromes did not occur in isolation (without other syndromes), except for multimorbidity (R, 1%; E, 5%), functional limitation (R, 3%; E, 2%), falls (R, 0%; E, 4%), and frailty (R, 2%; E, 5%), which occurred in isolation in some inpatients; sarcopenia did not.CONCLUSIONS: Geriatric syndromes are highly prevalent at admission to geriatric rehabilitation, with a median of 5 co-occurring syndromes. Implications for diagnosis and intervention potential should be further addressed.

AB - OBJECTIVE: To determine the prevalence and co-occurrence of common geriatric syndromes in geriatric rehabilitation inpatients.DESIGN: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR) are observational, longitudinal cohorts.SETTING: Geriatric rehabilitation.PARTICIPANTS: Geriatric rehabilitation inpatients (N=1890 and N=200).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Geriatric syndromes included polypharmacy, multimorbidity (Cumulative Illness Rating Scale), cognitive impairment, depression (Hospital Anxiety and Depression Scale/Geriatric Depression Scale), malnutrition (Global Leadership Initiative on Malnutrition), functional limitation (Katz index), falls, physical frailty (Fried), and sarcopenia (European Working Group on Sarcopenia in Older People 2).RESULTS: Inpatients in RESORT (R) (N=1890, 56% females) had a median age of 83.4 years (interquartile range [IQR], 77.6-88.4) and in EMPOWER-GR (E) (N=200, 57% females) of 79.8 years (IQR, 75.0-85.9). Polypharmacy (R, 82.2%; E, 84.0%), multimorbidity (R, 90.4%; E, 85.5%), functional limitation (R, 96.0%; E, 76.5%), and frailty (R, 91.8%; E, 92.2%) were most prevalent. Most inpatients had ≥5 geriatric syndromes at admission in both cohorts (R, 70.0%; E, 72.4%); few inpatients had only 1 (R, 0.4%; E, 1.5%) or no geriatric syndrome (R, 0.2%; E, 0.0%). Geriatric syndromes did not occur in isolation (without other syndromes), except for multimorbidity (R, 1%; E, 5%), functional limitation (R, 3%; E, 2%), falls (R, 0%; E, 4%), and frailty (R, 2%; E, 5%), which occurred in isolation in some inpatients; sarcopenia did not.CONCLUSIONS: Geriatric syndromes are highly prevalent at admission to geriatric rehabilitation, with a median of 5 co-occurring syndromes. Implications for diagnosis and intervention potential should be further addressed.

KW - Humans

KW - Female

KW - Male

KW - Aged

KW - Aged, 80 and over

KW - Accidental Falls/statistics & numerical data

KW - Polypharmacy

KW - Geriatric Assessment

KW - Multimorbidity

KW - Malnutrition/epidemiology

KW - Longitudinal Studies

KW - Sarcopenia/epidemiology

KW - Inpatients

KW - Frailty/rehabilitation

KW - Depression/epidemiology

KW - Syndrome

KW - Cognitive Dysfunction/rehabilitation

KW - Prevalence

KW - Muscle Strength

U2 - 10.1016/j.apmr.2024.05.021

DO - 10.1016/j.apmr.2024.05.021

M3 - Article

C2 - 38851557

SN - 0003-9993

VL - 105

SP - 1854

EP - 1861

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

IS - 10

ER -

Verstraeten LMG, Kreeftmeijer J, van Wijngaarden JP, Meskers CGM, Maier AB. Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR). Archives of Physical Medicine and Rehabilitation. 2024 Oct;105(10):1854-1861. Epub 2024 Jun 6. doi: 10.1016/j.apmr.2024.05.021

Geriatric Syndromes Frequently (Co)-Occur in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) and Enhancing Muscle Power in Geriatric Rehabilitation (EMPOWER-GR)

Abstract

Bibliographical note

Funding

Keywords

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