Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

L.M. Pardo; Z. Bochdanovits; E.J.C. de Geus; J.J. Hottenga; P.F. Sullivan; D. Posthuma; B.W.J.H. Penninx; D.I. Boomsma; P. Heutink

doi:10.1038/ejhg.2008.248

Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

L.M. Pardo, Z. Bochdanovits, E.J.C. de Geus, J.J. Hottenga, P.F. Sullivan, D. Posthuma, B.W.J.H. Penninx, D.I. Boomsma, P. Heutink

Biological Psychology

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Abstract

The HapMap project has facilitated the selection of tagging single nucleotide polymorphisms (tagSNPs) for genome-wide association studies (GWAS) under the assumption that linkage disequilibrium (LD) in the HapMap populations is similar to the populations under investigation. Earlier reports support this assumption, although in most of these studies only a few loci were evaluated. We compared pair-wise LD and LD block structure across autosomes between the Dutch population and the CEU-HapMap reference panel. The impact of sampling distribution on the estimation of LD blocks was studied by bootstrapping. A high Pearson correlation (genome-wide; 0.93) between pair-wise r

Original language	English
Pages (from-to)	802-810
Journal	European Journal of Human Genetics
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/ejhg.2008.248
Publication status	Published - 2009

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10.1038/ejhg.2008.248

Pardo EJHG 2009

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title = "Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations",

abstract = "The HapMap project has facilitated the selection of tagging single nucleotide polymorphisms (tagSNPs) for genome-wide association studies (GWAS) under the assumption that linkage disequilibrium (LD) in the HapMap populations is similar to the populations under investigation. Earlier reports support this assumption, although in most of these studies only a few loci were evaluated. We compared pair-wise LD and LD block structure across autosomes between the Dutch population and the CEU-HapMap reference panel. The impact of sampling distribution on the estimation of LD blocks was studied by bootstrapping. A high Pearson correlation (genome-wide; 0.93) between pair-wise r",

author = "L.M. Pardo and Z. Bochdanovits and {de Geus}, E.J.C. and J.J. Hottenga and P.F. Sullivan and D. Posthuma and B.W.J.H. Penninx and D.I. Boomsma and P. Heutink",

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AU - Pardo, L.M.

AU - Bochdanovits, Z.

AU - de Geus, E.J.C.

AU - Hottenga, J.J.

AU - Sullivan, P.F.

AU - Posthuma, D.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

AU - Heutink, P.

PY - 2009

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AB - The HapMap project has facilitated the selection of tagging single nucleotide polymorphisms (tagSNPs) for genome-wide association studies (GWAS) under the assumption that linkage disequilibrium (LD) in the HapMap populations is similar to the populations under investigation. Earlier reports support this assumption, although in most of these studies only a few loci were evaluated. We compared pair-wise LD and LD block structure across autosomes between the Dutch population and the CEU-HapMap reference panel. The impact of sampling distribution on the estimation of LD blocks was studied by bootstrapping. A high Pearson correlation (genome-wide; 0.93) between pair-wise r

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DO - 10.1038/ejhg.2008.248

M3 - Article

SN - 1018-4813

VL - 17

SP - 802

EP - 810

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 6

ER -

Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

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