Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

L.M. Pardo, Z. Bochdanovits, E.J.C. de Geus, J.J. Hottenga, P.F. Sullivan, D. Posthuma, B.W.J.H. Penninx, D.I. Boomsma, P. Heutink

Research output: Contribution to JournalArticle

Abstract

The HapMap project has facilitated the selection of tagging single nucleotide polymorphisms (tagSNPs) for genome-wide association studies (GWAS) under the assumption that linkage disequilibrium (LD) in the HapMap populations is similar to the populations under investigation. Earlier reports support this assumption, although in most of these studies only a few loci were evaluated. We compared pair-wise LD and LD block structure across autosomes between the Dutch population and the CEU-HapMap reference panel. The impact of sampling distribution on the estimation of LD blocks was studied by bootstrapping. A high Pearson correlation (genome-wide; 0.93) between pair-wise r
Original languageEnglish
Pages (from-to)802-810
JournalEuropean Journal of Human Genetics
Volume17
Issue number6
DOIs
Publication statusPublished - 2009

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