Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity

Isabelle Straub, Laurens Witter, Abdelmoneim Eshra, Miriam Hoidis, Niklas Byczkowicz, Sebastian Maas, Igor Delvendahl, Kevin Dorgans, Elise Savier, Ingo Bechmann, Martin Krueger, Philippe Isope, Stefan Hallermann

Research output: Contribution to JournalArticleAcademicpeer-review


Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain, but heterogeneities among GCs and potential functional consequences are poorly understood. Here, we identified unexpected gradients in the biophysical properties of GCs in mice. GCs closer to the white matter (inner-zone GCs) had higher firing thresholds and could sustain firing with larger current inputs than GCs closer to the Purkinje cell layer (outer-zone GCs). Dynamic Clamp experiments showed that inner- and outer-zone GCs preferentially respond to high- and low-frequency mossy fiber inputs, respectively, enabling dispersion of the mossy fiber input into its frequency components as performed by a Fourier transformation. Furthermore, inner-zone GCs have faster axonal conduction velocity and elicit faster synaptic potentials in Purkinje cells. Neuronal network modeling revealed that these gradients improve spike-timing precision of Purkinje cells and decrease the number of GCs required to learn spike-sequences. Thus, our study uncovers biophysical gradients in the cerebellar cortex enabling a Fourier-like transformation of mossy fiber inputs.

Original languageEnglish
Article numbere51771
Publication statusPublished - 5 Feb 2020

Bibliographical note

© 2020, Straub et al.


Dive into the research topics of 'Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity'. Together they form a unique fingerprint.

Cite this