Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga; Gaelle Doucet; Danai Dima; Ingrid Agartz; Moji Aghajani; Theophilus Akudjedu; Anton Albajes-Eizagirre; Dag Alnaes; Kathryn Alpert; Ole A Andreassen; Alan Anticevic; Philip Asherson; Tobias Banaschewski; Nuria Bargallo; Sarah Baumeister; Ramona Baur-Streubel; Alessandro Bertolino; Aurora Bonvino; Dorret Boomsma; Stefan Borgwardt; Josiane Bourque; Anouk den Braber; Daniel Brandeis; Alan Breier; Henry Brodaty; Rachel Brouwer; Geraldo Busatto; Vince Calhoun; Erick Canales-Rodriguez; Dara Cannon; Xavier Caseras; Tiffany Chaim-Avancini; Christopher Ching; Patricia Conrod; Annette Conzelmann; Fabrice Crivello; Christopher Davey; Erin Dickie; Stefan Ehrlich; Dennis van 't Ent; Jean-Paul Fouche; Paola Fuentes-Claramonte; Eco de Geus; Annabella Di Giorgio; David Glahn; Ian Gotlib; Hans Grabe; Oliver Gruber; Patricia Gruner; Raquel Gur; Ruben C Gur; Tiril P Gurholt; Lieuwe de Haan; Beathe Haatveit; Ben Harrison; Sean Hatton; Odile van den Heuvel; Ian Hickie; Sarah Hohmann; Avram N Holmes; Martine Hoogman; Norbert Hosten; Fleur Howells; Hilleke Hulshoff Pol; Chaim Huyser; Neda Jahanshad; Anthony James; Erik Jonsson; John Joska; Marieke Klein; Laura Koenders; Knut Kristian Kolskar; Bernd Kramer; Jonna Kuntsi; Jim Lagopoulos; Luisa Lazaro; Irina Lebedeva; Phil Hyoun Lee; Christine Lochner; Marise Machielsen; Sophie Maingault; Nicholas Martin; Ignacio Martinez-Zalacain; David Mataix-Cols; Bernard Mazoyer; Brenna McDonald; Colm McDonald; Andrew M McIntosh; Katie McMahon; Genevieve McPhilemy; Dennis van der Meer; Jose Menchon; Jilly Naaijen; Lars Nyberg; Yannis Paloyelis; Paul Pauli; Giulio Pergola; Edith Pomarol-Clotet; Maria Portella; Joaquim Radua; Andreas Reif; Genevieve Richard; Joshua Roffman; Pedro Rosa; Matthew Sacchet; Perminder Sachdev; Raymond Salvador; Salvador Sarro; Theodore Satterthwaite; Andrew Saykin; Mauricio Serpa; Kang Sim; Andrew Simmons; Jordan Smoller; Iris Sommer; Carles Soriano-Mas; Dan Stein; Lachlan Strike; Philip Szeszko; Henk Temmingh; Sophia Thomopoulos; Alexander Tomyshev; Julian Trollor; Anne Uhlmann; Ilya Veer; Dick Veltman; Aristotle Voineskos; Henry Volzke; Henrik Walter; Yang Wang; Lei Wang; Bernd J Weber; Wei Wen; John West; Lars T. Westlye; Heather C Whalley; Steven Williams; Katharina Wittfeld; Daniel Wolf; Margaret Wright; Yuliya Yoncheva; Marcus Zanetti; Georg Ziegler; Greig de Zubicaray; Paul Thompson; Eveline A Crone; Sophia Frangou; Christian K. Tamnes

doi:10.1101/2020.02.17.952010

Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan BorgwardtJosiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel Brouwer, Geraldo Busatto, Vince Calhoun, Erick Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany Chaim-Avancini, Christopher Ching, Patricia Conrod, Annette Conzelmann, Fabrice Crivello, Christopher Davey, Erin Dickie, Stefan Ehrlich, Dennis van 't Ent, Jean-Paul Fouche, Paola Fuentes-Claramonte, Eco de Geus, Annabella Di Giorgio, David Glahn, Ian Gotlib, Hans Grabe, Oliver Gruber, Patricia Gruner, Raquel Gur, Ruben C Gur, Tiril P Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben Harrison, Sean Hatton, Odile van den Heuvel, Ian Hickie, Sarah Hohmann, Avram N Holmes, Martine Hoogman, Norbert Hosten, Fleur Howells, Hilleke Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Erik Jonsson, John Joska, Marieke Klein, Laura Koenders, Knut Kristian Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Phil Hyoun Lee, Christine Lochner, Marise Machielsen, Sophie Maingault, Nicholas Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna McDonald, Colm McDonald, Andrew M McIntosh, Katie McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose Menchon, Jilly Naaijen, Lars Nyberg, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua Roffman, Pedro Rosa, Matthew Sacchet, Perminder Sachdev, Raymond Salvador, Salvador Sarro, Theodore Satterthwaite, Andrew Saykin, Mauricio Serpa, Kang Sim, Andrew Simmons, Jordan Smoller, Iris Sommer, Carles Soriano-Mas, Dan Stein, Lachlan Strike, Philip Szeszko, Henk Temmingh, Sophia Thomopoulos, Alexander Tomyshev, Julian Trollor, Anne Uhlmann, Ilya Veer, Dick Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Yang Wang, Lei Wang, Bernd J Weber, Wei Wen, John West, Lars T. Westlye, Heather C Whalley, Steven Williams, Katharina Wittfeld, Daniel Wolf, Margaret Wright, Yuliya Yoncheva, Marcus Zanetti, Georg Ziegler, Greig de Zubicaray, Paul Thompson, Eveline A Crone, Sophia Frangou, Christian K. Tamnes

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

Original language	English
Pages (from-to)	470-499
Number of pages	30
Journal	Human Brain Mapping
Volume	43
Issue number	1
Early online date	14 Aug 2020
DOIs	https://doi.org/10.1101/2020.02.17.952010
Publication status	Published - Jan 2022

Cohort Studies

Netherlands Twin Register (NTR)

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10.1101/2020.02.17.952010

https://www.biorxiv.org/content/10.1101/2020.02.17.952010v6

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Wierenga, L. M., Doucet, G., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T., Albajes-Eizagirre, A., Alnaes, D., Alpert, K., Andreassen, O. A., Anticevic, A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D., ... Tamnes, C. K. (2022). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping, 43(1), 470-499. https://doi.org/10.1101/2020.02.17.952010

Wierenga, Lara M ; Doucet, Gaelle ; Dima, Danai ; Agartz, Ingrid ; Aghajani, Moji ; Akudjedu, Theophilus ; Albajes-Eizagirre, Anton ; Alnaes, Dag ; Alpert, Kathryn ; Andreassen, Ole A ; Anticevic, Alan ; Asherson, Philip ; Banaschewski, Tobias ; Bargallo, Nuria ; Baumeister, Sarah ; Baur-Streubel, Ramona ; Bertolino, Alessandro ; Bonvino, Aurora ; Boomsma, Dorret ; Borgwardt, Stefan ; Bourque, Josiane ; Braber, Anouk den ; Brandeis, Daniel ; Breier, Alan ; Brodaty, Henry ; Brouwer, Rachel ; Busatto, Geraldo ; Calhoun, Vince ; Canales-Rodriguez, Erick ; Cannon, Dara ; Caseras, Xavier ; Chaim-Avancini, Tiffany ; Ching, Christopher ; Conrod, Patricia ; Conzelmann, Annette ; Crivello, Fabrice ; Davey, Christopher ; Dickie, Erin ; Ehrlich, Stefan ; Ent, Dennis van 't ; Fouche, Jean-Paul ; Fuentes-Claramonte, Paola ; Geus, Eco de ; Giorgio, Annabella Di ; Glahn, David ; Gotlib, Ian ; Grabe, Hans ; Gruber, Oliver ; Gruner, Patricia ; Gur, Raquel ; Gur, Ruben C ; Gurholt, Tiril P ; Haan, Lieuwe de ; Haatveit, Beathe ; Harrison, Ben ; Hatton, Sean ; Heuvel, Odile van den ; Hickie, Ian ; Hohmann, Sarah ; Holmes, Avram N ; Hoogman, Martine ; Hosten, Norbert ; Howells, Fleur ; Pol, Hilleke Hulshoff ; Huyser, Chaim ; Jahanshad, Neda ; James, Anthony ; Jonsson, Erik ; Joska, John ; Klein, Marieke ; Koenders, Laura ; Kolskar, Knut Kristian ; Kramer, Bernd ; Kuntsi, Jonna ; Lagopoulos, Jim ; Lazaro, Luisa ; Lebedeva, Irina ; Lee, Phil Hyoun ; Lochner, Christine ; Machielsen, Marise ; Maingault, Sophie ; Martin, Nicholas ; Martinez-Zalacain, Ignacio ; Mataix-Cols, David ; Mazoyer, Bernard ; McDonald, Brenna ; McDonald, Colm ; McIntosh, Andrew M ; McMahon, Katie ; McPhilemy, Genevieve ; Meer, Dennis van der ; Menchon, Jose ; Naaijen, Jilly ; Nyberg, Lars ; Paloyelis, Yannis ; Pauli, Paul ; Pergola, Giulio ; Pomarol-Clotet, Edith ; Portella, Maria ; Radua, Joaquim ; Reif, Andreas ; Richard, Genevieve ; Roffman, Joshua ; Rosa, Pedro ; Sacchet, Matthew ; Sachdev, Perminder ; Salvador, Raymond ; Sarro, Salvador ; Satterthwaite, Theodore ; Saykin, Andrew ; Serpa, Mauricio ; Sim, Kang ; Simmons, Andrew ; Smoller, Jordan ; Sommer, Iris ; Soriano-Mas, Carles ; Stein, Dan ; Strike, Lachlan ; Szeszko, Philip ; Temmingh, Henk ; Thomopoulos, Sophia ; Tomyshev, Alexander ; Trollor, Julian ; Uhlmann, Anne ; Veer, Ilya ; Veltman, Dick ; Voineskos, Aristotle ; Volzke, Henry ; Walter, Henrik ; Wang, Yang ; Wang, Lei ; Weber, Bernd J ; Wen, Wei ; West, John ; Westlye, Lars T. ; Whalley, Heather C ; Williams, Steven ; Wittfeld, Katharina ; Wolf, Daniel ; Wright, Margaret ; Yoncheva, Yuliya ; Zanetti, Marcus ; Ziegler, Georg ; Zubicaray, Greig de ; Thompson, Paul ; Crone, Eveline A ; Frangou, Sophia ; Tamnes, Christian K. / Greater male than female variability in regional brain structure across the lifespan. In: Human Brain Mapping. 2022 ; Vol. 43, No. 1. pp. 470-499.

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title = "Greater male than female variability in regional brain structure across the lifespan",

abstract = "For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.",

author = "Wierenga, {Lara M} and Gaelle Doucet and Danai Dima and Ingrid Agartz and Moji Aghajani and Theophilus Akudjedu and Anton Albajes-Eizagirre and Dag Alnaes and Kathryn Alpert and Andreassen, {Ole A} and Alan Anticevic and Philip Asherson and Tobias Banaschewski and Nuria Bargallo and Sarah Baumeister and Ramona Baur-Streubel and Alessandro Bertolino and Aurora Bonvino and Dorret Boomsma and Stefan Borgwardt and Josiane Bourque and Braber, {Anouk den} and Daniel Brandeis and Alan Breier and Henry Brodaty and Rachel Brouwer and Geraldo Busatto and Vince Calhoun and Erick Canales-Rodriguez and Dara Cannon and Xavier Caseras and Tiffany Chaim-Avancini and Christopher Ching and Patricia Conrod and Annette Conzelmann and Fabrice Crivello and Christopher Davey and Erin Dickie and Stefan Ehrlich and Ent, {Dennis van 't} and Jean-Paul Fouche and Paola Fuentes-Claramonte and Geus, {Eco de} and Giorgio, {Annabella Di} and David Glahn and Ian Gotlib and Hans Grabe and Oliver Gruber and Patricia Gruner and Raquel Gur and Gur, {Ruben C} and Gurholt, {Tiril P} and Haan, {Lieuwe de} and Beathe Haatveit and Ben Harrison and Sean Hatton and Heuvel, {Odile van den} and Ian Hickie and Sarah Hohmann and Holmes, {Avram N} and Martine Hoogman and Norbert Hosten and Fleur Howells and Pol, {Hilleke Hulshoff} and Chaim Huyser and Neda Jahanshad and Anthony James and Erik Jonsson and John Joska and Marieke Klein and Laura Koenders and Kolskar, {Knut Kristian} and Bernd Kramer and Jonna Kuntsi and Jim Lagopoulos and Luisa Lazaro and Irina Lebedeva and Lee, {Phil Hyoun} and Christine Lochner and Marise Machielsen and Sophie Maingault and Nicholas Martin and Ignacio Martinez-Zalacain and David Mataix-Cols and Bernard Mazoyer and Brenna McDonald and Colm McDonald and McIntosh, {Andrew M} and Katie McMahon and Genevieve McPhilemy and Meer, {Dennis van der} and Jose Menchon and Jilly Naaijen and Lars Nyberg and Yannis Paloyelis and Paul Pauli and Giulio Pergola and Edith Pomarol-Clotet and Maria Portella and Joaquim Radua and Andreas Reif and Genevieve Richard and Joshua Roffman and Pedro Rosa and Matthew Sacchet and Perminder Sachdev and Raymond Salvador and Salvador Sarro and Theodore Satterthwaite and Andrew Saykin and Mauricio Serpa and Kang Sim and Andrew Simmons and Jordan Smoller and Iris Sommer and Carles Soriano-Mas and Dan Stein and Lachlan Strike and Philip Szeszko and Henk Temmingh and Sophia Thomopoulos and Alexander Tomyshev and Julian Trollor and Anne Uhlmann and Ilya Veer and Dick Veltman and Aristotle Voineskos and Henry Volzke and Henrik Walter and Yang Wang and Lei Wang and Weber, {Bernd J} and Wei Wen and John West and Westlye, {Lars T.} and Whalley, {Heather C} and Steven Williams and Katharina Wittfeld and Daniel Wolf and Margaret Wright and Yuliya Yoncheva and Marcus Zanetti and Georg Ziegler and Zubicaray, {Greig de} and Paul Thompson and Crone, {Eveline A} and Sophia Frangou and Tamnes, {Christian K.}",

year = "2022",

month = jan,

doi = "10.1101/2020.02.17.952010",

language = "English",

volume = "43",

pages = "470--499",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "1",

}

Wierenga, LM, Doucet, G, Dima, D, Agartz, I, Aghajani, M, Akudjedu, T, Albajes-Eizagirre, A, Alnaes, D, Alpert, K, Andreassen, OA, Anticevic, A, Asherson, P, Banaschewski, T, Bargallo, N, Baumeister, S, Baur-Streubel, R, Bertolino, A, Bonvino, A, Boomsma, D, Borgwardt, S, Bourque, J, Braber, AD, Brandeis, D, Breier, A, Brodaty, H, Brouwer, R, Busatto, G, Calhoun, V, Canales-Rodriguez, E, Cannon, D, Caseras, X, Chaim-Avancini, T, Ching, C, Conrod, P, Conzelmann, A, Crivello, F, Davey, C, Dickie, E, Ehrlich, S, Ent, DV, Fouche, J-P, Fuentes-Claramonte, P, Geus, ED, Giorgio, AD, Glahn, D, Gotlib, I, Grabe, H, Gruber, O, Gruner, P, Gur, R, Gur, RC, Gurholt, TP, Haan, LD, Haatveit, B, Harrison, B, Hatton, S, Heuvel, OVD, Hickie, I, Hohmann, S, Holmes, AN, Hoogman, M, Hosten, N, Howells, F, Pol, HH, Huyser, C, Jahanshad, N, James, A, Jonsson, E, Joska, J, Klein, M, Koenders, L, Kolskar, KK, Kramer, B, Kuntsi, J, Lagopoulos, J, Lazaro, L, Lebedeva, I, Lee, PH, Lochner, C, Machielsen, M, Maingault, S, Martin, N, Martinez-Zalacain, I, Mataix-Cols, D, Mazoyer, B, McDonald, B, McDonald, C, McIntosh, AM, McMahon, K, McPhilemy, G, Meer, DVD, Menchon, J, Naaijen, J, Nyberg, L, Paloyelis, Y, Pauli, P, Pergola, G, Pomarol-Clotet, E, Portella, M, Radua, J, Reif, A, Richard, G, Roffman, J, Rosa, P, Sacchet, M, Sachdev, P, Salvador, R, Sarro, S, Satterthwaite, T, Saykin, A, Serpa, M, Sim, K, Simmons, A, Smoller, J, Sommer, I, Soriano-Mas, C, Stein, D, Strike, L, Szeszko, P, Temmingh, H, Thomopoulos, S, Tomyshev, A, Trollor, J, Uhlmann, A, Veer, I, Veltman, D, Voineskos, A, Volzke, H, Walter, H, Wang, Y, Wang, L, Weber, BJ, Wen, W, West, J, Westlye, LT, Whalley, HC, Williams, S, Wittfeld, K, Wolf, D, Wright, M, Yoncheva, Y, Zanetti, M, Ziegler, G, Zubicaray, GD, Thompson, P, Crone, EA, Frangou, S & Tamnes, CK 2022, 'Greater male than female variability in regional brain structure across the lifespan', Human Brain Mapping, vol. 43, no. 1, pp. 470-499. https://doi.org/10.1101/2020.02.17.952010

Greater male than female variability in regional brain structure across the lifespan. / Wierenga, Lara M; Doucet, Gaelle; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn; Andreassen, Ole A; Anticevic, Alan; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret; Borgwardt, Stefan; Bourque, Josiane; Braber, Anouk den; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel; Busatto, Geraldo; Calhoun, Vince; Canales-Rodriguez, Erick; Cannon, Dara; Caseras, Xavier; Chaim-Avancini, Tiffany; Ching, Christopher; Conrod, Patricia; Conzelmann, Annette; Crivello, Fabrice; Davey, Christopher; Dickie, Erin; Ehrlich, Stefan; Ent, Dennis van 't; Fouche, Jean-Paul; Fuentes-Claramonte, Paola; Geus, Eco de; Giorgio, Annabella Di; Glahn, David; Gotlib, Ian; Grabe, Hans; Gruber, Oliver; Gruner, Patricia; Gur, Raquel; Gur, Ruben C; Gurholt, Tiril P; Haan, Lieuwe de; Haatveit, Beathe; Harrison, Ben; Hatton, Sean; Heuvel, Odile van den; Hickie, Ian; Hohmann, Sarah; Holmes, Avram N; Hoogman, Martine; Hosten, Norbert; Howells, Fleur; Pol, Hilleke Hulshoff; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jonsson, Erik; Joska, John; Klein, Marieke; Koenders, Laura; Kolskar, Knut Kristian; Kramer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lazaro, Luisa; Lebedeva, Irina; Lee, Phil Hyoun; Lochner, Christine; Machielsen, Marise; Maingault, Sophie; Martin, Nicholas; Martinez-Zalacain, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Brenna; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie; McPhilemy, Genevieve; Meer, Dennis van der; Menchon, Jose; Naaijen, Jilly; Nyberg, Lars; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria; Radua, Joaquim; Reif, Andreas; Richard, Genevieve; Roffman, Joshua; Rosa, Pedro; Sacchet, Matthew; Sachdev, Perminder; Salvador, Raymond; Sarro, Salvador; Satterthwaite, Theodore; Saykin, Andrew; Serpa, Mauricio; Sim, Kang; Simmons, Andrew; Smoller, Jordan; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan; Strike, Lachlan; Szeszko, Philip; Temmingh, Henk; Thomopoulos, Sophia; Tomyshev, Alexander; Trollor, Julian; Uhlmann, Anne; Veer, Ilya; Veltman, Dick; Voineskos, Aristotle; Volzke, Henry; Walter, Henrik; Wang, Yang; Wang, Lei; Weber, Bernd J; Wen, Wei; West, John; Westlye, Lars T.; Whalley, Heather C; Williams, Steven; Wittfeld, Katharina; Wolf, Daniel; Wright, Margaret; Yoncheva, Yuliya; Zanetti, Marcus; Ziegler, Georg; Zubicaray, Greig de; Thompson, Paul; Crone, Eveline A; Frangou, Sophia; Tamnes, Christian K.

In: Human Brain Mapping, Vol. 43, No. 1, 01.2022, p. 470-499.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Greater male than female variability in regional brain structure across the lifespan

AU - Wierenga, Lara M

AU - Doucet, Gaelle

AU - Dima, Danai

AU - Agartz, Ingrid

AU - Aghajani, Moji

AU - Akudjedu, Theophilus

AU - Albajes-Eizagirre, Anton

AU - Alnaes, Dag

AU - Alpert, Kathryn

AU - Andreassen, Ole A

AU - Anticevic, Alan

AU - Asherson, Philip

AU - Banaschewski, Tobias

AU - Bargallo, Nuria

AU - Baumeister, Sarah

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bonvino, Aurora

AU - Boomsma, Dorret

AU - Borgwardt, Stefan

AU - Bourque, Josiane

AU - Braber, Anouk den

AU - Brandeis, Daniel

AU - Breier, Alan

AU - Brodaty, Henry

AU - Brouwer, Rachel

AU - Busatto, Geraldo

AU - Calhoun, Vince

AU - Canales-Rodriguez, Erick

AU - Cannon, Dara

AU - Caseras, Xavier

AU - Chaim-Avancini, Tiffany

AU - Ching, Christopher

AU - Conrod, Patricia

AU - Conzelmann, Annette

AU - Crivello, Fabrice

AU - Davey, Christopher

AU - Dickie, Erin

AU - Ehrlich, Stefan

AU - Ent, Dennis van 't

AU - Fouche, Jean-Paul

AU - Fuentes-Claramonte, Paola

AU - Geus, Eco de

AU - Giorgio, Annabella Di

AU - Glahn, David

AU - Gotlib, Ian

AU - Grabe, Hans

AU - Gruber, Oliver

AU - Gruner, Patricia

AU - Gur, Raquel

AU - Gur, Ruben C

AU - Gurholt, Tiril P

AU - Haan, Lieuwe de

AU - Haatveit, Beathe

AU - Harrison, Ben

AU - Hatton, Sean

AU - Heuvel, Odile van den

AU - Hickie, Ian

AU - Hohmann, Sarah

AU - Holmes, Avram N

AU - Hoogman, Martine

AU - Hosten, Norbert

AU - Howells, Fleur

AU - Pol, Hilleke Hulshoff

AU - Huyser, Chaim

AU - Jahanshad, Neda

AU - James, Anthony

AU - Jonsson, Erik

AU - Joska, John

AU - Klein, Marieke

AU - Koenders, Laura

AU - Kolskar, Knut Kristian

AU - Kramer, Bernd

AU - Kuntsi, Jonna

AU - Lagopoulos, Jim

AU - Lazaro, Luisa

AU - Lebedeva, Irina

AU - Lee, Phil Hyoun

AU - Lochner, Christine

AU - Machielsen, Marise

AU - Maingault, Sophie

AU - Martin, Nicholas

AU - Martinez-Zalacain, Ignacio

AU - Mataix-Cols, David

AU - Mazoyer, Bernard

AU - McDonald, Brenna

AU - McDonald, Colm

AU - McIntosh, Andrew M

AU - McMahon, Katie

AU - McPhilemy, Genevieve

AU - Meer, Dennis van der

AU - Menchon, Jose

AU - Naaijen, Jilly

AU - Nyberg, Lars

AU - Paloyelis, Yannis

AU - Pauli, Paul

AU - Pergola, Giulio

AU - Pomarol-Clotet, Edith

AU - Portella, Maria

AU - Radua, Joaquim

AU - Reif, Andreas

AU - Richard, Genevieve

AU - Roffman, Joshua

AU - Rosa, Pedro

AU - Sacchet, Matthew

AU - Sachdev, Perminder

AU - Salvador, Raymond

AU - Sarro, Salvador

AU - Satterthwaite, Theodore

AU - Saykin, Andrew

AU - Serpa, Mauricio

AU - Sim, Kang

AU - Simmons, Andrew

AU - Smoller, Jordan

AU - Sommer, Iris

AU - Soriano-Mas, Carles

AU - Stein, Dan

AU - Strike, Lachlan

AU - Szeszko, Philip

AU - Temmingh, Henk

AU - Thomopoulos, Sophia

AU - Tomyshev, Alexander

AU - Trollor, Julian

AU - Uhlmann, Anne

AU - Veer, Ilya

AU - Veltman, Dick

AU - Voineskos, Aristotle

AU - Volzke, Henry

AU - Walter, Henrik

AU - Wang, Yang

AU - Wang, Lei

AU - Weber, Bernd J

AU - Wen, Wei

AU - West, John

AU - Westlye, Lars T.

AU - Whalley, Heather C

AU - Williams, Steven

AU - Wittfeld, Katharina

AU - Wolf, Daniel

AU - Wright, Margaret

AU - Yoncheva, Yuliya

AU - Zanetti, Marcus

AU - Ziegler, Georg

AU - Zubicaray, Greig de

AU - Thompson, Paul

AU - Crone, Eveline A

AU - Frangou, Sophia

AU - Tamnes, Christian K.

PY - 2022/1

Y1 - 2022/1

N2 - For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

AB - For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

UR - https://www.mendeley.com/catalogue/24875add-fa6b-3b33-a5c0-c03e2955ab44/

U2 - 10.1101/2020.02.17.952010

DO - 10.1101/2020.02.17.952010

M3 - Article

VL - 43

SP - 470

EP - 499

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 1

ER -

Greater male than female variability in regional brain structure across the lifespan

Abstract

Cohort Studies

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