Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2020.02.17.952010 |
| Journal | bioRxiv |
| DOIs | |
| Publication status | Published - 2020 |
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Greater male than female variability in regional brain structure across the lifespan. / Wierenga, Lara M; Doucet, Gaelle; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn; Andreassen, Ole A; Anticevic, Alan; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret; Borgwardt, Stefan; Bourque, Josiane; Braber, Anouk den; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel; Busatto, Geraldo; Calhoun, Vince; Canales-Rodriguez, Erick; Cannon, Dara; Caseras, Xavier; Chaim-Avancini, Tiffany; Ching, Christopher; Conrod, Patricia; Conzelmann, Annette; Crivello, Fabrice; Davey, Christopher; Dickie, Erin; Ehrlich, Stefan; Ent, Dennis van 't; Fouche, Jean-Paul; Fuentes-Claramonte, Paola; Geus, Eco de; Giorgio, Annabella Di; Glahn, David; Gotlib, Ian; Grabe, Hans; Gruber, Oliver; Gruner, Patricia; Gur, Raquel; Gur, Ruben C; Gurholt, Tiril P; Haan, Lieuwe de; Haatveit, Beathe; Harrison, Ben; Hatton, Sean; Heuvel, Odile van den; Hickie, Ian; Hohmann, Sarah; Holmes, Avram N; Hoogman, Martine; Hosten, Norbert; Howells, Fleur; Pol, Hilleke Hulshoff; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jonsson, Erik; Joska, John; Klein, Marieke; Koenders, Laura; Kolskar, Knut Kristian; Kramer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lazaro, Luisa; Lebedeva, Irina; Lee, Phil Hyoun; Lochner, Christine; Machielsen, Marise; Maingault, Sophie; Martin, Nicholas; Martinez-Zalacain, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Brenna; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie; McPhilemy, Genevieve; Meer, Dennis van der; Menchon, Jose; Naaijen, Jilly; Nyberg, Lars; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria; Radua, Joaquim; Reif, Andreas; Richard, Genevieve; Roffman, Joshua; Rosa, Pedro; Sacchet, Matthew; Sachdev, Perminder; Salvador, Raymond; Sarro, Salvador; Satterthwaite, Theodore; Saykin, Andrew; Serpa, Mauricio; Sim, Kang; Simmons, Andrew; Smoller, Jordan; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan; Strike, Lachlan; Szeszko, Philip; Temmingh, Henk; Thomopoulos, Sophia; Tomyshev, Alexander; Trollor, Julian; Uhlmann, Anne; Veer, Ilya; Veltman, Dick; Voineskos, Aristotle; Volzke, Henry; Walter, Henrik; Wang, Yang; Wang, Lei; Weber, Bernd J; Wen, Wei; West, John; Westlye, Lars T.; Whalley, Heather C; Williams, Steven; Wittfeld, Katharina; Wolf, Daniel; Wright, Margaret; Yoncheva, Yuliya; Zanetti, Marcus; Ziegler, Georg; Zubicaray, Greig de; Thompson, Paul; Crone, Eveline A; Frangou, Sophia; Tamnes, Christian K.
In: bioRxiv, 2020, p. 2020.02.17.952010.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Greater male than female variability in regional brain structure across the lifespan
AU - Wierenga, Lara M
AU - Doucet, Gaelle
AU - Dima, Danai
AU - Agartz, Ingrid
AU - Aghajani, Moji
AU - Akudjedu, Theophilus
AU - Albajes-Eizagirre, Anton
AU - Alnaes, Dag
AU - Alpert, Kathryn
AU - Andreassen, Ole A
AU - Anticevic, Alan
AU - Asherson, Philip
AU - Banaschewski, Tobias
AU - Bargallo, Nuria
AU - Baumeister, Sarah
AU - Baur-Streubel, Ramona
AU - Bertolino, Alessandro
AU - Bonvino, Aurora
AU - Boomsma, Dorret
AU - Borgwardt, Stefan
AU - Bourque, Josiane
AU - Braber, Anouk den
AU - Brandeis, Daniel
AU - Breier, Alan
AU - Brodaty, Henry
AU - Brouwer, Rachel
AU - Busatto, Geraldo
AU - Calhoun, Vince
AU - Canales-Rodriguez, Erick
AU - Cannon, Dara
AU - Caseras, Xavier
AU - Chaim-Avancini, Tiffany
AU - Ching, Christopher
AU - Conrod, Patricia
AU - Conzelmann, Annette
AU - Crivello, Fabrice
AU - Davey, Christopher
AU - Dickie, Erin
AU - Ehrlich, Stefan
AU - Ent, Dennis van 't
AU - Fouche, Jean-Paul
AU - Fuentes-Claramonte, Paola
AU - Geus, Eco de
AU - Giorgio, Annabella Di
AU - Glahn, David
AU - Gotlib, Ian
AU - Grabe, Hans
AU - Gruber, Oliver
AU - Gruner, Patricia
AU - Gur, Raquel
AU - Gur, Ruben C
AU - Gurholt, Tiril P
AU - Haan, Lieuwe de
AU - Haatveit, Beathe
AU - Harrison, Ben
AU - Hatton, Sean
AU - Heuvel, Odile van den
AU - Hickie, Ian
AU - Hohmann, Sarah
AU - Holmes, Avram N
AU - Hoogman, Martine
AU - Hosten, Norbert
AU - Howells, Fleur
AU - Pol, Hilleke Hulshoff
AU - Huyser, Chaim
AU - Jahanshad, Neda
AU - James, Anthony
AU - Jonsson, Erik
AU - Joska, John
AU - Klein, Marieke
AU - Koenders, Laura
AU - Kolskar, Knut Kristian
AU - Kramer, Bernd
AU - Kuntsi, Jonna
AU - Lagopoulos, Jim
AU - Lazaro, Luisa
AU - Lebedeva, Irina
AU - Lee, Phil Hyoun
AU - Lochner, Christine
AU - Machielsen, Marise
AU - Maingault, Sophie
AU - Martin, Nicholas
AU - Martinez-Zalacain, Ignacio
AU - Mataix-Cols, David
AU - Mazoyer, Bernard
AU - McDonald, Brenna
AU - McDonald, Colm
AU - McIntosh, Andrew M
AU - McMahon, Katie
AU - McPhilemy, Genevieve
AU - Meer, Dennis van der
AU - Menchon, Jose
AU - Naaijen, Jilly
AU - Nyberg, Lars
AU - Paloyelis, Yannis
AU - Pauli, Paul
AU - Pergola, Giulio
AU - Pomarol-Clotet, Edith
AU - Portella, Maria
AU - Radua, Joaquim
AU - Reif, Andreas
AU - Richard, Genevieve
AU - Roffman, Joshua
AU - Rosa, Pedro
AU - Sacchet, Matthew
AU - Sachdev, Perminder
AU - Salvador, Raymond
AU - Sarro, Salvador
AU - Satterthwaite, Theodore
AU - Saykin, Andrew
AU - Serpa, Mauricio
AU - Sim, Kang
AU - Simmons, Andrew
AU - Smoller, Jordan
AU - Sommer, Iris
AU - Soriano-Mas, Carles
AU - Stein, Dan
AU - Strike, Lachlan
AU - Szeszko, Philip
AU - Temmingh, Henk
AU - Thomopoulos, Sophia
AU - Tomyshev, Alexander
AU - Trollor, Julian
AU - Uhlmann, Anne
AU - Veer, Ilya
AU - Veltman, Dick
AU - Voineskos, Aristotle
AU - Volzke, Henry
AU - Walter, Henrik
AU - Wang, Yang
AU - Wang, Lei
AU - Weber, Bernd J
AU - Wen, Wei
AU - West, John
AU - Westlye, Lars T.
AU - Whalley, Heather C
AU - Williams, Steven
AU - Wittfeld, Katharina
AU - Wolf, Daniel
AU - Wright, Margaret
AU - Yoncheva, Yuliya
AU - Zanetti, Marcus
AU - Ziegler, Georg
AU - Zubicaray, Greig de
AU - Thompson, Paul
AU - Crone, Eveline A
AU - Frangou, Sophia
AU - Tamnes, Christian K.
PY - 2020
Y1 - 2020
N2 - For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
AB - For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed patterns of greater male than female between-subject variance for all brain measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
UR - https://www.mendeley.com/catalogue/24875add-fa6b-3b33-a5c0-c03e2955ab44/
U2 - 10.1101/2020.02.17.952010
DO - 10.1101/2020.02.17.952010
M3 - Article
SP - 2020.02.17.952010
JO - bioRxiv
JF - bioRxiv
ER -