TY - JOUR
T1 - Hapten-induced hypersensitivity reactions in the airways
T2 - Atopic versus non-atopic
AU - Van Houwelingen, A.H.
AU - Kraneveld, A.D.
AU - Nijkamp, F.P.
PY - 2002
Y1 - 2002
N2 - Hypersensitivity reactions induced by low molecular weight compounds are investigated extensively in the skin. However, these reactions can also occur in the lungs of previously sensitized individuals after local airway challenge. This hapten-induced pulmonary hypersensitivity reaction resembles features observed in asthmatic patients, such as bronchial hyperreactivity, accumulation of inflammatory cells, and airway edema. We review data that hapten-induced hypersensitivity reactions in mouse airways can be models for both atopic and non-atopic asthma associated with low molecular weight compounds. © 2002 Elsevier Science B.V. All rights reserved.
AB - Hypersensitivity reactions induced by low molecular weight compounds are investigated extensively in the skin. However, these reactions can also occur in the lungs of previously sensitized individuals after local airway challenge. This hapten-induced pulmonary hypersensitivity reaction resembles features observed in asthmatic patients, such as bronchial hyperreactivity, accumulation of inflammatory cells, and airway edema. We review data that hapten-induced hypersensitivity reactions in mouse airways can be models for both atopic and non-atopic asthma associated with low molecular weight compounds. © 2002 Elsevier Science B.V. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=0036290287&partnerID=8YFLogxK
U2 - 10.1016/S1382-6689(02)00007-8
DO - 10.1016/S1382-6689(02)00007-8
M3 - Article
SN - 1382-6689
VL - 11
SP - 197
EP - 205
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
IS - 3-4
ER -
