Health-related quality of life associated with diabetic retinopathy in patients at a public primary care service in Southern Brazil

Ângela Jornada Ben*, Camila Furtado de Souza, Franciele Locatelli, Ana Paula Oliveira Rosses, Adriana Szortika, Aline Lutz de Araujo, Gabriela de Carvalho, Daniel Lavinsky, Jeruza Lavanholi Neyeloff, Cristina Rolim Neumann

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective

This study aimed to establish the utility values of different health states associated with diabetic retinopathy in a Brazilian sample to provide input to model-based economic evaluations.

Subjects and methods

This cross-sectional study was performed in a sample of patients with type 2 diabetes mellitus (T2D) who underwent teleophthalmology screening at a primary care service from 2014 to 2016. Five diabetic retinopathy health states were defined: absent, non-sight-threatening, sight-threatening, and bilateral blindness. Utility values were estimated using the Brazilian EuroQol five dimensions (EQ-5D) tariffs. Descriptive statistics were calculated. Analysis of covariance was performed to adjust the utility values for potential confounders.

Results

The study included 206 patients. The mean (± standard deviation [SD]) utility value was 0.765 ± 0.19 (95% confidence interval [CI], 0.740–0.790). The adjusted mean utility value was 0.748 (95% CI, 0.698–0.798) in patients without diabetic retinopathy, 0.752 (95% CI, 0.679–0.825) in those with non-sight-threatening state, 0.628 (95% CI, 0.521–0.736) in those with sight-threatening state, and 0.355 (95% CI, 0.105–0.606) in those with bilateral blindness. A significant utility decrement was found between patients without diabetic retinopathy and those with a sight-threatening health state (0.748 vs. 0.628, respectively, p = 0.04).

Conclusions

The findings suggest that a later diabetic retinopathy health state is associated with a decrement in utility value compared with the absence of retinopathy in patients with T2D. The results may be useful as preliminary input to model-based economic evaluations. Further research is needed to investigate the impact of diabetic retinopathy on health-related quality of life in a sample more representative of the Brazilian population.
Original languageEnglish
Pages (from-to)575-583
Number of pages9
JournalArchives of Endocrinology and Metabolism
Volume64
Issue number5
Early online date6 Apr 2020
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Diabetic retinopathy
  • EQ-5D
  • Health-related quality of life
  • Utility values

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