Health-related quality of life of people with HIV: An assessment of patient related factors and comparison with other chronic diseases

Esther A.N. Engelhard, Colette Smit, Peter R. Van Dijk, T. Martijn Kuijper, Paulien R. Wermeling, Angelique E. Weel, Michiel R. De Boer, Kees Brinkman, Suzanne E. Geerlings, Pythia T. Nieuwkerk

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objectives: The health-related quality of life (HRQOL) of people with HIV is lower than in the general population, but it is unknown how it compares with that of persons with other chronic medical conditions. We compared HRQOL in HIV with HRQOL in diabetes mellitus type 1, diabetes mellitus type 2 and rheumatoid arthritis (RA). In addition, we investigated factors associated with HRQOL in HIV. Design: Cross-sectional study. Methods: HRQOL was measured with the Medical Outcomes Study Short Form 36-item Health Survey in a nationwide sample of people with HIV in care in the Netherlands and on combination antiretroviral therapy for at least 6 months. We added data from studies in diabetes mellitus types 1 and 2, and RA. Logistic regression analysis was used to examine: The association between disease group and a poor HRQOL, and patient factors associated with poor HRQOL in HIV. Results: The odds of a poor physical HRQOL in the HIV group were comparable with the odds in diabetes mellitus types 1 and 2, but lower than in RA patients. The odds of a poor mental HRQOL in HIV were higher than in the other groups. In HIV, a history of AIDS, longer duration of combination antiretroviral therapy and severe comorbidity were associated with a poor physical HRQOL. Sub-Saharan African descent and CD4 + cell count of less than 350 cells/μl were associated with poor mental HRQOL. Conclusion: People with HIV were more likely to have a poor mental HRQOL than patients with other chronic conditions. Addressing mental health should be an integral part of outpatient HIV care.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalAIDS
Volume32
Issue number1
DOIs
Publication statusPublished - 2 Jan 2018

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Chronic Disease
Quality of Life
HIV
Mental Health
Type 1 Diabetes Mellitus
Rheumatoid Arthritis
Type 2 Diabetes Mellitus
CD4 Lymphocyte Count
Ambulatory Care
Health Surveys
Netherlands
Comorbidity
Diabetes Mellitus
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)
Therapeutics

Keywords

  • chronic disease
  • diabetes mellitus
  • health-related quality of life
  • HIV
  • rheumatoid arthritis

Cite this

Engelhard, E. A. N., Smit, C., Van Dijk, P. R., Kuijper, T. M., Wermeling, P. R., Weel, A. E., ... Nieuwkerk, P. T. (2018). Health-related quality of life of people with HIV: An assessment of patient related factors and comparison with other chronic diseases. AIDS, 32(1), 103-112. https://doi.org/10.1097/QAD.0000000000001672
Engelhard, Esther A.N. ; Smit, Colette ; Van Dijk, Peter R. ; Kuijper, T. Martijn ; Wermeling, Paulien R. ; Weel, Angelique E. ; De Boer, Michiel R. ; Brinkman, Kees ; Geerlings, Suzanne E. ; Nieuwkerk, Pythia T. / Health-related quality of life of people with HIV : An assessment of patient related factors and comparison with other chronic diseases. In: AIDS. 2018 ; Vol. 32, No. 1. pp. 103-112.
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abstract = "Objectives: The health-related quality of life (HRQOL) of people with HIV is lower than in the general population, but it is unknown how it compares with that of persons with other chronic medical conditions. We compared HRQOL in HIV with HRQOL in diabetes mellitus type 1, diabetes mellitus type 2 and rheumatoid arthritis (RA). In addition, we investigated factors associated with HRQOL in HIV. Design: Cross-sectional study. Methods: HRQOL was measured with the Medical Outcomes Study Short Form 36-item Health Survey in a nationwide sample of people with HIV in care in the Netherlands and on combination antiretroviral therapy for at least 6 months. We added data from studies in diabetes mellitus types 1 and 2, and RA. Logistic regression analysis was used to examine: The association between disease group and a poor HRQOL, and patient factors associated with poor HRQOL in HIV. Results: The odds of a poor physical HRQOL in the HIV group were comparable with the odds in diabetes mellitus types 1 and 2, but lower than in RA patients. The odds of a poor mental HRQOL in HIV were higher than in the other groups. In HIV, a history of AIDS, longer duration of combination antiretroviral therapy and severe comorbidity were associated with a poor physical HRQOL. Sub-Saharan African descent and CD4 + cell count of less than 350 cells/μl were associated with poor mental HRQOL. Conclusion: People with HIV were more likely to have a poor mental HRQOL than patients with other chronic conditions. Addressing mental health should be an integral part of outpatient HIV care.",
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Engelhard, EAN, Smit, C, Van Dijk, PR, Kuijper, TM, Wermeling, PR, Weel, AE, De Boer, MR, Brinkman, K, Geerlings, SE & Nieuwkerk, PT 2018, 'Health-related quality of life of people with HIV: An assessment of patient related factors and comparison with other chronic diseases' AIDS, vol. 32, no. 1, pp. 103-112. https://doi.org/10.1097/QAD.0000000000001672

Health-related quality of life of people with HIV : An assessment of patient related factors and comparison with other chronic diseases. / Engelhard, Esther A.N.; Smit, Colette; Van Dijk, Peter R.; Kuijper, T. Martijn; Wermeling, Paulien R.; Weel, Angelique E.; De Boer, Michiel R.; Brinkman, Kees; Geerlings, Suzanne E.; Nieuwkerk, Pythia T.

In: AIDS, Vol. 32, No. 1, 02.01.2018, p. 103-112.

Research output: Contribution to JournalArticleAcademicpeer-review

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T2 - An assessment of patient related factors and comparison with other chronic diseases

AU - Engelhard, Esther A.N.

AU - Smit, Colette

AU - Van Dijk, Peter R.

AU - Kuijper, T. Martijn

AU - Wermeling, Paulien R.

AU - Weel, Angelique E.

AU - De Boer, Michiel R.

AU - Brinkman, Kees

AU - Geerlings, Suzanne E.

AU - Nieuwkerk, Pythia T.

PY - 2018/1/2

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N2 - Objectives: The health-related quality of life (HRQOL) of people with HIV is lower than in the general population, but it is unknown how it compares with that of persons with other chronic medical conditions. We compared HRQOL in HIV with HRQOL in diabetes mellitus type 1, diabetes mellitus type 2 and rheumatoid arthritis (RA). In addition, we investigated factors associated with HRQOL in HIV. Design: Cross-sectional study. Methods: HRQOL was measured with the Medical Outcomes Study Short Form 36-item Health Survey in a nationwide sample of people with HIV in care in the Netherlands and on combination antiretroviral therapy for at least 6 months. We added data from studies in diabetes mellitus types 1 and 2, and RA. Logistic regression analysis was used to examine: The association between disease group and a poor HRQOL, and patient factors associated with poor HRQOL in HIV. Results: The odds of a poor physical HRQOL in the HIV group were comparable with the odds in diabetes mellitus types 1 and 2, but lower than in RA patients. The odds of a poor mental HRQOL in HIV were higher than in the other groups. In HIV, a history of AIDS, longer duration of combination antiretroviral therapy and severe comorbidity were associated with a poor physical HRQOL. Sub-Saharan African descent and CD4 + cell count of less than 350 cells/μl were associated with poor mental HRQOL. Conclusion: People with HIV were more likely to have a poor mental HRQOL than patients with other chronic conditions. Addressing mental health should be an integral part of outpatient HIV care.

AB - Objectives: The health-related quality of life (HRQOL) of people with HIV is lower than in the general population, but it is unknown how it compares with that of persons with other chronic medical conditions. We compared HRQOL in HIV with HRQOL in diabetes mellitus type 1, diabetes mellitus type 2 and rheumatoid arthritis (RA). In addition, we investigated factors associated with HRQOL in HIV. Design: Cross-sectional study. Methods: HRQOL was measured with the Medical Outcomes Study Short Form 36-item Health Survey in a nationwide sample of people with HIV in care in the Netherlands and on combination antiretroviral therapy for at least 6 months. We added data from studies in diabetes mellitus types 1 and 2, and RA. Logistic regression analysis was used to examine: The association between disease group and a poor HRQOL, and patient factors associated with poor HRQOL in HIV. Results: The odds of a poor physical HRQOL in the HIV group were comparable with the odds in diabetes mellitus types 1 and 2, but lower than in RA patients. The odds of a poor mental HRQOL in HIV were higher than in the other groups. In HIV, a history of AIDS, longer duration of combination antiretroviral therapy and severe comorbidity were associated with a poor physical HRQOL. Sub-Saharan African descent and CD4 + cell count of less than 350 cells/μl were associated with poor mental HRQOL. Conclusion: People with HIV were more likely to have a poor mental HRQOL than patients with other chronic conditions. Addressing mental health should be an integral part of outpatient HIV care.

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