Health technology assessment in the era of personalized health care.

L. Becla, J.E. Lunshof, D. Gurwitz, T. Schulte in de Baumen, H.V. Westerhoff, B. Lange, A. Brand

Research output: Contribution to JournalArticleAcademicpeer-review


Objectives: This article examines the challenges for health technology assessment (HTA) in the light of new developments of personalized health care, focusing on European HTA perspectives. Methods: Using the example of the Integrated Genome Research Network - Mutanom (IG Mutanom) project, with focus on personalized cancer diagnostics and treatment, we assess the scope of current HTA and examine it prospectively in the context of the translation of basic and clinical research into public health genomics and personalized health care. Results: The approaches developed within the IG-Mutanom project are based on innovative technology potentially providing targeted therapies for cancer; making translation into clinical practice requires a novel course of action, however. New models of HTA are needed that can account for the unique types of evidence inherent to individualized targeted therapies. Using constructive health technology assessment (CTA) models is an option, but further suitable models should be developed. Conclusions: Integrative, systems biology-based approaches toward personalized medicine call for novel assessment methods. The translation of their highly innovative technologies into the practice of health care requires the development of new HTA concepts. © 2011 Cambridge University Press.
Original languageEnglish
Pages (from-to)118-126
JournalInternational Journal of Technology Assessessment in Health Care
Publication statusPublished - 2011


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