Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Magda Drewniak, Ewelina Węglarz-Tomczak, Katarzyna Ożga, Ewa Rudzińska-Szostak, Katarzyna Macegoniuk, Jakub M. Tomczak, Magdalena Bejger, Wojciech Rypniewski, Łukasz Berlicki

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalBioorganic Chemistry
Volume81
DOIs
Publication statusPublished - 1 Dec 2018
Externally publishedYes

Fingerprint

Hydrolases
Cycloleucine
Peptides
Enzymes
Nuclear magnetic resonance spectroscopy
Hydrogen
Hydrogen bonds
Magnetic Resonance Spectroscopy
Molecules

Keywords

  • Catalysis
  • Circular dichroism
  • Conformation
  • Foldamers
  • Nuclear magnetic resonance
  • Peptides

Cite this

Drewniak, M., Węglarz-Tomczak, E., Ożga, K., Rudzińska-Szostak, E., Macegoniuk, K., Tomczak, J. M., ... Berlicki, Ł. (2018). Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics. Bioorganic Chemistry, 81, 356-361. https://doi.org/10.1016/j.bioorg.2018.07.012
Drewniak, Magda ; Węglarz-Tomczak, Ewelina ; Ożga, Katarzyna ; Rudzińska-Szostak, Ewa ; Macegoniuk, Katarzyna ; Tomczak, Jakub M. ; Bejger, Magdalena ; Rypniewski, Wojciech ; Berlicki, Łukasz. / Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics. In: Bioorganic Chemistry. 2018 ; Vol. 81. pp. 356-361.
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Drewniak, M, Węglarz-Tomczak, E, Ożga, K, Rudzińska-Szostak, E, Macegoniuk, K, Tomczak, JM, Bejger, M, Rypniewski, W & Berlicki, Ł 2018, 'Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics' Bioorganic Chemistry, vol. 81, pp. 356-361. https://doi.org/10.1016/j.bioorg.2018.07.012

Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics. / Drewniak, Magda; Węglarz-Tomczak, Ewelina; Ożga, Katarzyna; Rudzińska-Szostak, Ewa; Macegoniuk, Katarzyna; Tomczak, Jakub M.; Bejger, Magdalena; Rypniewski, Wojciech; Berlicki, Łukasz.

In: Bioorganic Chemistry, Vol. 81, 01.12.2018, p. 356-361.

Research output: Contribution to JournalArticleAcademicpeer-review

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