Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Magda Drewniak; Ewelina Węglarz-Tomczak; Katarzyna Ożga; Ewa Rudzińska-Szostak; Katarzyna Macegoniuk; Jakub M. Tomczak; Magdalena Bejger; Wojciech Rypniewski; Łukasz Berlicki

doi:10.1016/j.bioorg.2018.07.012

Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Magda Drewniak, Ewelina Węglarz-Tomczak, Katarzyna Ożga, Ewa Rudzińska-Szostak, Katarzyna Macegoniuk, Jakub M. Tomczak, Magdalena Bejger, Wojciech Rypniewski, Łukasz Berlicki^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.

Original language	English
Pages (from-to)	356-361
Number of pages	6
Journal	Bioorganic Chemistry
Volume	81
DOIs	https://doi.org/10.1016/j.bioorg.2018.07.012
Publication status	Published - 1 Dec 2018
Externally published	Yes

Funding

The work was financed by the National Science Centre, Poland (Grant No. DEC-2013/10/E/ST5/00625 ). Appendix A

Funders	Funder number
Narodowe Centrum Nauki	DEC-2013/10/E/ST5/00625
Narodowym Centrum Nauki

Keywords

Catalysis
Circular dichroism
Conformation
Foldamers
Nuclear magnetic resonance
Peptides

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10.1016/j.bioorg.2018.07.012

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title = "Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics",

abstract = "De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.",

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doi = "10.1016/j.bioorg.2018.07.012",

language = "English",

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journal = "Bioorganic Chemistry",

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T1 - Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

AU - Drewniak, Magda

AU - Węglarz-Tomczak, Ewelina

AU - Ożga, Katarzyna

AU - Rudzińska-Szostak, Ewa

AU - Macegoniuk, Katarzyna

AU - Tomczak, Jakub M.

AU - Bejger, Magdalena

AU - Rypniewski, Wojciech

AU - Berlicki, Łukasz

PY - 2018/12/1

Y1 - 2018/12/1

N2 - De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.

AB - De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.

KW - Catalysis

KW - Circular dichroism

KW - Conformation

KW - Foldamers

KW - Nuclear magnetic resonance

KW - Peptides

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JO - Bioorganic Chemistry

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ER -

Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Abstract

Funding

Keywords

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