Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Magda Drewniak, Ewelina Węglarz-Tomczak, Katarzyna Ożga, Ewa Rudzińska-Szostak, Katarzyna Macegoniuk, Jakub M. Tomczak, Magdalena Bejger, Wojciech Rypniewski, Łukasz Berlicki*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalBioorganic Chemistry
Volume81
DOIs
Publication statusPublished - 1 Dec 2018
Externally publishedYes

Keywords

  • Catalysis
  • Circular dichroism
  • Conformation
  • Foldamers
  • Nuclear magnetic resonance
  • Peptides

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