Heritability estimates of body size in fetal life and early childhood

D.O. Mook-Kanamori; C.E.M. van Beijsterveldt; E.A. Steegers; Y.S. Aulchenko; H. Raat; A. Hofman; P.H.C. Eilers; D.I. Boomsma; V.W.V. Jaddoe

doi:10.1371/journal.pone.0039901

Heritability estimates of body size in fetal life and early childhood

D.O. Mook-Kanamori, C.E.M. van Beijsterveldt, E.A. Steegers, Y.S. Aulchenko, H. Raat, A. Hofman, P.H.C. Eilers, D.I. Boomsma, V.W.V. Jaddoe

Biological Psychology

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Abstract

Background: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins. Methods: This study was embedded in the Generation R Study (n = 3407, singletons) and the Netherlands Twin Register (n = 33694, twins). For the heritability estimates in Generation R, regression models as proposed by Galton were used. In the Twin Register we used genetic structural equation modelling. Parental height and weight were measured and fetal growth characteristics (femur length and estimated fetal weight) were measured by ultrasounds in 2

Original language	English
Article number	e39901
Journal	PLoS ONE
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0039901
Publication status	Published - 2012

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abstract = "Background: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins. Methods: This study was embedded in the Generation R Study (n = 3407, singletons) and the Netherlands Twin Register (n = 33694, twins). For the heritability estimates in Generation R, regression models as proposed by Galton were used. In the Twin Register we used genetic structural equation modelling. Parental height and weight were measured and fetal growth characteristics (femur length and estimated fetal weight) were measured by ultrasounds in 2",

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AU - Mook-Kanamori, D.O.

AU - van Beijsterveldt, C.E.M.

AU - Steegers, E.A.

AU - Aulchenko, Y.S.

AU - Raat, H.

AU - Hofman, A.

AU - Eilers, P.H.C.

AU - Boomsma, D.I.

AU - Jaddoe, V.W.V.

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