Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data

P. Kochunov, N. Jahanshad, D. Marcus, A. Winkler, E. Sprooten, T.E. Nichols, S.N. Wright, L.E. Hong, B. Patel, T. Behrens, S. Jbabdi, J. Andersson, C. Lenglet, E. Yacoub, S. Moeller, E. Auerbach, K. Ugurbil, S.N. Sotiropoulos, R.M. Brouwer, B. LandmanH. Lemaitre, A. den Braber, M.P. Zwiers, S. Ritchie, K.J.E. van Hulzen, L. Almasy, J. Curran, G.I. de Zubicaray, R. Duggirala, P. Fox, N.G. Martin, K.L. McMahon, B. Mitchell, R.L. Olvera, C. Peterson, J. Starr, J.E. Sussmann, J.M. Wardlaw, M. Wright, D.I. Boomsma, R.S. Kahn, E.J.C. de Geus, D.E. Williamson, A. Hariri, D. van t Ent, M.E. Bastin, A. McIntosh, I.J. Deary, H.E. Hulshoff Pol, J. Blangero, P.M. Thompson, D.C. Glahn, D.C. van Essen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h
Original languageEnglish
Pages (from-to)300-311
Number of pages12
JournalNeuroImage
Volume111
DOIs
Publication statusPublished - 2015

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