Heritability of Volumetric Brain Changes and Height in Children Entering Puberty

I.L.C. van Soelen, R.M. Brouwer, G.C.M. van Baal, H.G. Schnack, J.S. Peper, L. Chen, R.S. Kahn, D.I. Boomsma, H.E. Hulshoff Pol

Research output: Contribution to JournalArticleAcademicpeer-review


The human brain undergoes structural changes in children entering puberty, while simultaneously children increase in height. It is not known if brain changes are under genetic control, and whether they are related to genetic factors influencing the amount of overall increase in height. Twins underwent magnetic resonance imaging brain scans at age 9 (N = 190) and 12 (N = 125). High heritability estimates were found at both ages for height and brain volumes (49-96%), and high genetic correlation between ages were observed (r
Original languageEnglish
Pages (from-to)713-725
JournalHuman Brain Mapping
Issue number3
Early online date3 Dec 2011
Publication statusPublished - 2013

Cohort Studies

  • Netherlands Twin Register (NTR)


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