Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae.

S.L. Rossell Aragort, C.C. van der Weijden, A.L. Kruckeberg, B.M. Bakker, H.V. Westerhoff

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A novel method dissecting the regulation of a cellular function into direct metabolic regulation and hierarchical (e.g., gene-expression) regulation is applied to yeast starved for nitrogen or carbon. Upon nitrogen starvation glucose influx is down-regulated hierarchically. Upon carbon starvation it is down-regulated both metabolically and hierarchically. The method is expounded in terms of its implications for diverse types of regulation. It is also fine-tuned for cases where isoenzymes catalyze the flux through a single metabolic step. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalFEMS Yeast Research
Volume5
DOIs
Publication statusPublished - 2005

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