High abstinence rates in heroin addicts by a new comprehensive treatment approach

C.A.J. de Jong, H.G. Roozen, L.G.M. van Rossum, P.F.M. Krabbe, A.J.F.M. Kerkhof

Research output: Contribution to JournalArticleAcademicpeer-review

245 Downloads (Pure)


In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.
Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalAmerican Journal on Addictions
Issue number2
Publication statusPublished - 2007


Dive into the research topics of 'High abstinence rates in heroin addicts by a new comprehensive treatment approach'. Together they form a unique fingerprint.

Cite this