TY - JOUR
T1 - High abstinence rates in heroin addicts by a new comprehensive treatment approach
AU - de Jong, C.A.J.
AU - Roozen, H.G.
AU - van Rossum, L.G.M.
AU - Krabbe, P.F.M.
AU - Kerkhof, A.J.F.M.
PY - 2007
Y1 - 2007
N2 - In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.
AB - In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.
U2 - 10.1080/10550490601184472
DO - 10.1080/10550490601184472
M3 - Article
VL - 16
SP - 124
EP - 130
JO - American Journal on Addictions
JF - American Journal on Addictions
SN - 1055-0496
IS - 2
ER -