High abstinence rates in heroin addicts by a new comprehensive treatment approach

C.A.J. de Jong; H.G. Roozen; L.G.M. van Rossum; P.F.M. Krabbe; A.J.F.M. Kerkhof

doi:10.1080/10550490601184472

High abstinence rates in heroin addicts by a new comprehensive treatment approach

C.A.J. de Jong, H.G. Roozen, L.G.M. van Rossum, P.F.M. Krabbe, A.J.F.M. Kerkhof

Clinical Psychology

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Abstract

In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.

Original language	English
Pages (from-to)	124-130
Number of pages	7
Journal	American Journal on Addictions
Volume	16
Issue number	2
DOIs	https://doi.org/10.1080/10550490601184472
Publication status	Published - 2007

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Jong, de American Journal on Addiction 16(2) 2007 uFinal published version, 145 KB

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title = "High abstinence rates in heroin addicts by a new comprehensive treatment approach",

abstract = "In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.",

author = "{de Jong}, C.A.J. and H.G. Roozen and {van Rossum}, L.G.M. and P.F.M. Krabbe and A.J.F.M. Kerkhof",

year = "2007",

doi = "10.1080/10550490601184472",

language = "English",

volume = "16",

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journal = "American Journal on Addictions",

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T1 - High abstinence rates in heroin addicts by a new comprehensive treatment approach

AU - de Jong, C.A.J.

AU - Roozen, H.G.

AU - van Rossum, L.G.M.

AU - Krabbe, P.F.M.

AU - Kerkhof, A.J.F.M.

PY - 2007

Y1 - 2007

N2 - In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.

AB - In this multi-center, naturalistic study, the effectiveness of naltrexone maintenance combined with the Community Reinforcement Approach (CRA) was investigated in detoxified, opioid-dependent patients (N=272). Patients were recruited from methadone maintenance programs. With intention-to-treat analysis, 10 months of treatment yielded abstinence rates of 28% and 32% at 10 and 16 months after detoxification. The cumulative abstinence rate at 16 months was 24%. Quality of life, craving, general psychopathology, use of other psychoactive substances, and addiction severity of the abstinent group significantly improved when compared to the relapsed group. This abstinence-oriented approach appears to be a feasible goal, and remains an important option next to long-term methadone maintenance in the management of opioid dependence.

U2 - 10.1080/10550490601184472

DO - 10.1080/10550490601184472

M3 - Article

VL - 16

SP - 124

EP - 130

JO - American Journal on Addictions

JF - American Journal on Addictions

SN - 1055-0496

IS - 2

ER -

High abstinence rates in heroin addicts by a new comprehensive treatment approach

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