High local substrate availability stabilizes a cooperative trait.

H. Bachmann, D. Molenaar, M. Kleerebezem, J.E.T. van Hylckama Vlieg

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Cooperative behavior is widely spread in microbial populations. An example is the expression of an extracellular protease by the lactic acid bacterium Lactococcus lactis, which degrades milk proteins into free utilizable peptides that are essential to allow growth to high cell densities in milk. Cheating, protease-negative strains can invade the population and drive the protease-positive strain to extinction. By using multiple experimental approaches, as well as modeling population dynamics, we demonstrate that the persistence of the proteolytic trait is determined by the fraction of the generated peptides that can be captured by the cell before diffusing away from it. The mechanism described is likely to be relevant for the evolutionary stability of many extracellular substrate-degrading enzymes. © 2011 International Society for Microbial Ecology All rights reserved.
Original languageEnglish
Pages (from-to)929-932
JournalISME Journal
Volume5
DOIs
Publication statusPublished - 2011

Fingerprint

peptide
milk
cooperatives
Peptide Hydrolases
proteinases
cooperative behavior
substrate
microbial ecology
peptides
population dynamics
Lactococcus lactis
Peptides
persistence
enzyme substrates
Milk Proteins
extinction
milk proteins
Population Dynamics
enzyme
Ecology

Cite this

Bachmann, H. ; Molenaar, D. ; Kleerebezem, M. ; van Hylckama Vlieg, J.E.T. / High local substrate availability stabilizes a cooperative trait. In: ISME Journal. 2011 ; Vol. 5. pp. 929-932.
@article{23e0cea259e64ef486625fcf5c3b025c,
title = "High local substrate availability stabilizes a cooperative trait.",
abstract = "Cooperative behavior is widely spread in microbial populations. An example is the expression of an extracellular protease by the lactic acid bacterium Lactococcus lactis, which degrades milk proteins into free utilizable peptides that are essential to allow growth to high cell densities in milk. Cheating, protease-negative strains can invade the population and drive the protease-positive strain to extinction. By using multiple experimental approaches, as well as modeling population dynamics, we demonstrate that the persistence of the proteolytic trait is determined by the fraction of the generated peptides that can be captured by the cell before diffusing away from it. The mechanism described is likely to be relevant for the evolutionary stability of many extracellular substrate-degrading enzymes. {\circledC} 2011 International Society for Microbial Ecology All rights reserved.",
author = "H. Bachmann and D. Molenaar and M. Kleerebezem and {van Hylckama Vlieg}, J.E.T.",
year = "2011",
doi = "10.1038/ismej.2010.179",
language = "English",
volume = "5",
pages = "929--932",
journal = "The ISME Journal",
issn = "1751-7362",
publisher = "Nature Publishing Group",

}

High local substrate availability stabilizes a cooperative trait. / Bachmann, H.; Molenaar, D.; Kleerebezem, M.; van Hylckama Vlieg, J.E.T.

In: ISME Journal, Vol. 5, 2011, p. 929-932.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - High local substrate availability stabilizes a cooperative trait.

AU - Bachmann, H.

AU - Molenaar, D.

AU - Kleerebezem, M.

AU - van Hylckama Vlieg, J.E.T.

PY - 2011

Y1 - 2011

N2 - Cooperative behavior is widely spread in microbial populations. An example is the expression of an extracellular protease by the lactic acid bacterium Lactococcus lactis, which degrades milk proteins into free utilizable peptides that are essential to allow growth to high cell densities in milk. Cheating, protease-negative strains can invade the population and drive the protease-positive strain to extinction. By using multiple experimental approaches, as well as modeling population dynamics, we demonstrate that the persistence of the proteolytic trait is determined by the fraction of the generated peptides that can be captured by the cell before diffusing away from it. The mechanism described is likely to be relevant for the evolutionary stability of many extracellular substrate-degrading enzymes. © 2011 International Society for Microbial Ecology All rights reserved.

AB - Cooperative behavior is widely spread in microbial populations. An example is the expression of an extracellular protease by the lactic acid bacterium Lactococcus lactis, which degrades milk proteins into free utilizable peptides that are essential to allow growth to high cell densities in milk. Cheating, protease-negative strains can invade the population and drive the protease-positive strain to extinction. By using multiple experimental approaches, as well as modeling population dynamics, we demonstrate that the persistence of the proteolytic trait is determined by the fraction of the generated peptides that can be captured by the cell before diffusing away from it. The mechanism described is likely to be relevant for the evolutionary stability of many extracellular substrate-degrading enzymes. © 2011 International Society for Microbial Ecology All rights reserved.

U2 - 10.1038/ismej.2010.179

DO - 10.1038/ismej.2010.179

M3 - Article

VL - 5

SP - 929

EP - 932

JO - The ISME Journal

JF - The ISME Journal

SN - 1751-7362

ER -