TY - GEN
T1 - Higher-Order Adaptive Dynamical System Modelling of the Role of Epigenetics in Major Depressive Disorder
AU - Magielse, Taylor
AU - Lage, Diana Pena
AU - Van Lieshout, Isabel
AU - Treur, Jan
N1 - Publisher Copyright:
© IFIP International Federation for Information Processing 2024.
PY - 2024
Y1 - 2024
N2 - This paper focuses on the modelling of an experiment concerning the emotional response as a result of thinking about happy memories for non-depressed and depressed individuals. Furthermore, it shows the role of epigenetic changes in this experiment by showing that the depletion of the brain-derived neurotrophic factor (BDNF) gene expression, often associated in literature both with depression and memory functions, can lead to a depressed individual and a change of feeling state with happy memory recall. An adaptive dynamical system model was designed for this process, which involves higher-order adaptation in emotion regulation. This computational model was represented as a higher-order adaptive network model and showcases an individual who, at first, does not have a major depressive disorder (MDD), but then a stressful life event happens, leading to epigenetic changes associated with BDNF depletion that make the person develop depression.
AB - This paper focuses on the modelling of an experiment concerning the emotional response as a result of thinking about happy memories for non-depressed and depressed individuals. Furthermore, it shows the role of epigenetic changes in this experiment by showing that the depletion of the brain-derived neurotrophic factor (BDNF) gene expression, often associated in literature both with depression and memory functions, can lead to a depressed individual and a change of feeling state with happy memory recall. An adaptive dynamical system model was designed for this process, which involves higher-order adaptation in emotion regulation. This computational model was represented as a higher-order adaptive network model and showcases an individual who, at first, does not have a major depressive disorder (MDD), but then a stressful life event happens, leading to epigenetic changes associated with BDNF depletion that make the person develop depression.
UR - https://www.scopus.com/pages/publications/85197358761
UR - https://www.scopus.com/pages/publications/85197358761#tab=citedBy
U2 - 10.1007/978-3-031-63211-2_7
DO - 10.1007/978-3-031-63211-2_7
M3 - Conference contribution
AN - SCOPUS:85197358761
SN - 9783031632105
SN - 9783031632136
VL - 1
T3 - IFIP Advances in Information and Communication Technology
SP - 79
EP - 90
BT - Artificial Intelligence Applications and Innovations
A2 - Maglogiannis, Ilias
A2 - Iliadis, Lazaros
A2 - Papaleonidas, Antonios
A2 - Macintyre, John
A2 - Avlonitis, Markos
PB - Springer Science and Business Media Deutschland GmbH
T2 - 20th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2024
Y2 - 27 June 2024 through 30 June 2024
ER -