Abstract
Time and pep-tide wait for no man: Optically pure 3,4disubstituted 1-pyrrolines, generated from the corresponding meso-pyrrolidines by biocatalytic desymmetrization (MAO-N=monoamine oxidase N), react with carboxylic acids and isocyanides in a highly diastereoselective Ugi-type multicomponent reaction to give substituted prolyl peptides of high pharmaceutical relevance. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Original language | English |
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Pages (from-to) | 5289-5292 |
Number of pages | 4 |
Journal | Angewandte Chemie International Edition in English |
Volume | 49 |
Issue number | 31 |
DOIs | |
Publication status | Published - 2010 |
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Dive into the research topics of 'Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions'. Together they form a unique fingerprint.Datasets
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CCDC 769733: Experimental Crystal Structure Determination
Znabet, A. (Contributor), Ruijter, E. (Contributor), De Kanter, F. J. J. (Contributor), Kohler, V. (Contributor), Helliwell, M. (Contributor), Turner, N. J. (Contributor) & Orru, R. V. A. (Contributor), Unknown Publisher, 19 Jul 2010
DOI: 10.5517/ccttz3p, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccttz3p&sid=DataCite
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