Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions

A. Znabet, E. Ruijter, F.J.J. de Kanter, V. Köhler, M. Helliwell, N.J. Turner, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Time and pep-tide wait for no man: Optically pure 3,4disubstituted 1-pyrrolines, generated from the corresponding meso-pyrrolidines by biocatalytic desymmetrization (MAO-N=monoamine oxidase N), react with carboxylic acids and isocyanides in a highly diastereoselective Ugi-type multicomponent reaction to give substituted prolyl peptides of high pharmaceutical relevance. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)5289-5292
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume49
Issue number31
DOIs
Publication statusPublished - 2010

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