Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration

Madelon M.E. Riem; Marinus H. van IJzendoorn; Marian J. Bakermans-Kranenburg

doi:10.1016/j.psyneuen.2018.11.015

Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration

Madelon M.E. Riem^*
, Marinus H. van IJzendoorn
, Marian J. Bakermans-Kranenburg

^*Corresponding author for this work

Clinical Child and Family Studies

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.

Original language	English
Pages (from-to)	182-185
Number of pages	4
Journal	Psychoneuroendocrinology
Volume	101
Early online date	12 Nov 2018
DOIs	https://doi.org/10.1016/j.psyneuen.2018.11.015
Publication status	Published - Mar 2019

Funding

MJB-K and MHvIJ are supported by research awards from the Netherlands Organization for Scientific Research (MHvIJ: SPINOZA prize; MJBK: VICI grant), and MJB-K is supported by the European Research Council (ERC AdG) . MJB-K and MHvIJ are involved in the Consortium on Individual Development which is funded through the Gravitation program of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NWO grant number 024.001.003).

Funders	Funder number
Dutch Ministry of Education, Culture, and Science
Horizon 2020 Framework Programme	669249
European Research Council
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.001.003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 16 Peace, Justice and Strong Institutions

Keywords

Childhood adversity
Emotional maltreatment
Hippocampus
MRI
Oxytocin

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10.1016/j.psyneuen.2018.11.015

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title = "Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration",

abstract = "Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.",

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AU - Riem, Madelon M.E.

AU - van IJzendoorn, Marinus H.

AU - Bakermans-Kranenburg, Marian J.

PY - 2019/3

Y1 - 2019/3

N2 - Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.

AB - Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.

KW - Childhood adversity

KW - Emotional maltreatment

KW - Hippocampus

KW - MRI

KW - Oxytocin

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Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration

Abstract

Funding

UN SDGs

Keywords

Access to Document

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