Histamine H3 receptor agonists

I J P De Esch; K J Belzar

doi:10.2174/1389557043403134

Histamine H3 receptor agonists

I J P De Esch, K J Belzar

Medicinal chemistry

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

Original language	English
Pages (from-to)	955-63
Number of pages	9
Journal	Mini-Reviews in Medicinal Chemistry
Volume	4
Issue number	9
DOIs	https://doi.org/10.2174/1389557043403134
Publication status	Published - Nov 2004

Keywords

Animals
Histamine Agonists
Humans
Ligands
Receptors, Histamine H3
Stereoisomerism
Structure-Activity Relationship
Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1389557043403134

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@article{2d4928dc62ff4bed9ea70850a70aff83,

title = "Histamine H3 receptor agonists",

abstract = "The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.",

keywords = "Animals, Histamine Agonists, Humans, Ligands, Receptors, Histamine H3, Stereoisomerism, Structure-Activity Relationship, Journal Article, Review",

author = "{De Esch}, {I J P} and Belzar, {K J}",

year = "2004",

month = nov,

doi = "10.2174/1389557043403134",

language = "English",

volume = "4",

pages = "955--63",

journal = "Mini-Reviews in Medicinal Chemistry",

issn = "1389-5575",

publisher = "Bentham Science Publishers B.V.",

number = "9",

}

TY - JOUR

T1 - Histamine H3 receptor agonists

AU - De Esch, I J P

AU - Belzar, K J

PY - 2004/11

Y1 - 2004/11

N2 - The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

AB - The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

KW - Animals

KW - Histamine Agonists

KW - Humans

KW - Ligands

KW - Receptors, Histamine H3

KW - Stereoisomerism

KW - Structure-Activity Relationship

KW - Journal Article

KW - Review

U2 - 10.2174/1389557043403134

DO - 10.2174/1389557043403134

M3 - Review article

C2 - 15544556

SN - 1389-5575

VL - 4

SP - 955

EP - 963

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

IS - 9

ER -

Histamine H3 receptor agonists

Abstract

Keywords

UN SDGs

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