Abstract
Prolonged exposure of the guinea-pig intestinal longitudinal smooth muscle to histamine caused homologous desensitization of the H1 receptor, which led to reduced H1 receptor-mediated production of [3H]inositol phosphates as well as to reduced H1 agonist-induced contractions. [3H]Mepyramine binding studies showed that desensitization affected neither the agonist affinity nor the number of H1 receptors. Combining the data from the binding studies and the contraction measurements it was found that desensitization results in a selective reduction of agonist efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 319-22 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 196 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 24 Apr 1991 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Animals
- Guinea Pigs
- Histamine
- In Vitro Techniques
- Inositol Phosphates
- Jejunum
- Male
- Membranes
- Muscle Contraction
- Muscle, Smooth
- Phosphatidylinositols
- Pyridines
- Pyrilamine
- Receptors, Histamine H1
- Tritium
- Journal Article
Fingerprint
Dive into the research topics of 'Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver