Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities

J. Venhorst; A.M. ter Laak; J.N.M. Commandeur; Y. Funae; T. Hiroi; N.P.E. Vermeulen

doi:10.1021/jm0209578

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities

J. Venhorst
, A.M. ter Laak
, J.N.M. Commandeur
, Y. Funae
, T. Hiroi
, N.P.E. Vermeulen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by measuring IC

Original language	English
Pages (from-to)	74-86
Journal	Journal of Medicinal Chemistry
Volume	46
Issue number	1
DOIs	https://doi.org/10.1021/jm0209578
Publication status	Published - 2003

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SDG 3 Good Health and Well-being

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10.1021/jm0209578

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@article{4134e84ecdd8492788abf42606750646,

title = "Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities",

abstract = "The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by measuring IC",

author = "J. Venhorst and \{ter Laak\}, A.M. and J.N.M. Commandeur and Y. Funae and T. Hiroi and N.P.E. Vermeulen",

year = "2003",

doi = "10.1021/jm0209578",

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volume = "46",

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T1 - Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities

AU - Venhorst, J.

AU - ter Laak, A.M.

AU - Commandeur, J.N.M.

AU - Funae, Y.

AU - Hiroi, T.

AU - Vermeulen, N.P.E.

PY - 2003

Y1 - 2003

N2 - The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by measuring IC

AB - The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by measuring IC

U2 - 10.1021/jm0209578

DO - 10.1021/jm0209578

M3 - Article

SN - 0022-2623

VL - 46

SP - 74

EP - 86

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 1

ER -

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities

Abstract

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