How Dihalogens Catalyze Michael Addition Reactions

Trevor A. Hamlin, Israel Fernández*, F. Matthias Bickelhaupt

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


We have quantum chemically analyzed the catalytic effect of dihalogen molecules (X2=F2, Cl2, Br2, and I2) on the aza-Michael addition of pyrrolidine and methyl acrylate using relativistic density functional theory and coupled-cluster theory. Our state-of-the-art computations reveal that activation barriers systematically decrease as one goes to heavier dihalogens, from 9.4 kcal mol−1 for F2 to 5.7 kcal mol−1 for I2. Activation strain and bonding analyses identify an unexpected physical factor that controls the computed reactivity trends, namely, Pauli repulsion between the nucleophile and Michael acceptor. Thus, dihalogens do not accelerate Michael additions by the commonly accepted mechanism of an enhanced donor–acceptor [HOMO(nucleophile)–LUMO(Michael acceptor)] interaction, but instead through a diminished Pauli repulsion between the lone-pair of the nucleophile and the Michael acceptor's π-electron system.

Original languageEnglish
Pages (from-to)8922-8926
Number of pages5
JournalAngewandte Chemie. International Edition
Issue number26
Publication statusPublished - 24 Jun 2019


  • activation strain model
  • density functional calculations
  • halogen bonding
  • Michael addition
  • Pauli repulsion
  • reactivity


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