How does hip osteoarthritis differ from knee osteoarthritis?

M Hall, M van der Esch, R S Hinman, G Peat, A de Zwart, J G Quicke, J Runhaar, J Knoop, M van der Leeden, M de Rooij, I Meulenbelt, T Vliet Vlieland, W F Lems, M A Holden, N E Foster, K L Bennell

Research output: Contribution to JournalReview articleAcademicpeer-review


Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating results from research on knee OA may limit our understanding of disease characteristics specific to hip OA, thereby constraining development and implementation of effective treatments. This review highlights differences between hip and knee OA with respect to prevalence, prognosis, epigenetics, pathophysiology, anatomical and biomechanical factors, clinical presentation, pain and non-surgical treatment recommendations and management.

Original languageEnglish
Pages (from-to)32-41
Number of pages10
JournalOsteoarthritis and Cartilage
Issue number1
Early online date29 Sept 2021
Publication statusPublished - Jan 2022

Bibliographical note

Copyright © 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.


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