HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

M. Bierkens, S.M. Wilting, W.N. van Wieringen, M. van de Wiel, B. Ylstra, C.J.L.M. Meijer, P.J.F. Snijders, R.D.M. Steenbergen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.Methods: Chromosomal profiles were determined of 43 p16
Original languageEnglish
Article number36
JournalBMC Cancer
Volume12
DOIs
Publication statusPublished - 2012

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