HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

M. Bierkens; S.M. Wilting; W.N. van Wieringen; M. van de Wiel; B. Ylstra; C.J.L.M. Meijer; P.J.F. Snijders; R.D.M. Steenbergen

doi:10.1186/1471-2407-12-36

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

M. Bierkens
, S.M. Wilting
, W.N. van Wieringen
, M. van de Wiel
, B. Ylstra
, C.J.L.M. Meijer
, P.J.F. Snijders
, R.D.M. Steenbergen

Mathematics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.Methods: Chromosomal profiles were determined of 43 p16

Original language	English
Article number	36
Journal	BMC Cancer
Volume	12
DOIs	https://doi.org/10.1186/1471-2407-12-36
Publication status	Published - 2012

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title = "HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia",

abstract = "Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.Methods: Chromosomal profiles were determined of 43 p16",

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T1 - HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

AU - Bierkens, M.

AU - Wilting, S.M.

AU - van Wieringen, W.N.

AU - van de Wiel, M.

AU - Ylstra, B.

AU - Meijer, C.J.L.M.

AU - Snijders, P.J.F.

AU - Steenbergen, R.D.M.

PY - 2012

Y1 - 2012

N2 - Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.Methods: Chromosomal profiles were determined of 43 p16

AB - Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected.Methods: Chromosomal profiles were determined of 43 p16

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U2 - 10.1186/1471-2407-12-36

DO - 10.1186/1471-2407-12-36

M3 - Article

SN - 1471-2407

VL - 12

JO - BMC Cancer

JF - BMC Cancer

M1 - 36

ER -

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

Abstract

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