Human twinning is not linked to the region of chromosome 4 syntetic with the sheep twinning gene FecB

DL Duffy, GW Montgomery, J. Hall, C. Mayne, S.C. Healy, J Brown, D.I. Boomsma, N.G. Martin

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Abstract

The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (λ
Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume100
Issue number3
DOIs
Publication statusPublished - 2001

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