Human twinning is not linked to the region of chromosome 4 syntetic with the sheep twinning gene FecB

DL Duffy; GW Montgomery; J. Hall; C. Mayne; S.C. Healy; J Brown; D.I. Boomsma; N.G. Martin

doi:10.1002/ajmg.1255

Human twinning is not linked to the region of chromosome 4 syntetic with the sheep twinning gene FecB

DL Duffy, GW Montgomery, J. Hall, C. Mayne, S.C. Healy, J Brown, D.I. Boomsma, N.G. Martin

Biological Psychology

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Abstract

The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (λ

Original language	English
Pages (from-to)	182-186
Number of pages	5
Journal	American Journal of Medical Genetics
Volume	100
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.1255
Publication status	Published - 2001

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Netherlands Twin Register (NTR)

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Duffy American journal of medical genetics 100(3) 2001 uFinal published version, 113 KB

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR_publicaties/DuffyChr4.pdf

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title = "Human twinning is not linked to the region of chromosome 4 syntetic with the sheep twinning gene FecB",

abstract = "The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (λ",

author = "DL Duffy and GW Montgomery and J. Hall and C. Mayne and S.C. Healy and J Brown and D.I. Boomsma and N.G. Martin",

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AU - Duffy, DL

AU - Montgomery, GW

AU - Hall, J.

AU - Mayne, C.

AU - Healy, S.C.

AU - Brown, J

AU - Boomsma, D.I.

AU - Martin, N.G.

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AB - The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (λ

U2 - 10.1002/ajmg.1255

DO - 10.1002/ajmg.1255

M3 - Article

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JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

IS - 3

ER -

Human twinning is not linked to the region of chromosome 4 syntetic with the sheep twinning gene FecB

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UN SDGs

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