Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.

J.G.M. Bessems, M.J. de Groot, E.J. Baede, J.M. te Koppele, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH
Original languageEnglish
Pages (from-to)855-875
JournalXenobiotica
Volume28
Issue number9
DOIs
Publication statusPublished - 1998

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