Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.

J.G.M. Bessems; M.J. de Groot; E.J. Baede; J.M. te Koppele; N.P.E. Vermeulen

doi:10.1080/004982598239100

Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.

J.G.M. Bessems, M.J. de Groot, E.J. Baede, J.M. te Koppele, N.P.E. Vermeulen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH

Original language	English
Pages (from-to)	855-875
Journal	Xenobiotica
Volume	28
Issue number	9
DOIs	https://doi.org/10.1080/004982598239100
Publication status	Published - 1998

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10.1080/004982598239100

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title = "Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.",

abstract = "1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH",

author = "J.G.M. Bessems and \{de Groot\}, M.J. and E.J. Baede and \{te Koppele\}, J.M. and N.P.E. Vermeulen",

year = "1998",

doi = "10.1080/004982598239100",

language = "English",

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pages = "855--875",

journal = "Xenobiotica",

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T1 - Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.

AU - Bessems, J.G.M.

AU - de Groot, M.J.

AU - Baede, E.J.

AU - te Koppele, J.M.

AU - Vermeulen, N.P.E.

PY - 1998

Y1 - 1998

N2 - 1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH

AB - 1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH

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U2 - 10.1080/004982598239100

DO - 10.1080/004982598239100

M3 - Article

SN - 0049-8254

VL - 28

SP - 855

EP - 875

JO - Xenobiotica

JF - Xenobiotica

IS - 9

ER -

Hydrogen atom abstraction of 3,5 disubstitued analogues of paracetemol by horseradish peroxidase and cytochrome P450.

Abstract

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