Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia

Y.M. Geng; D.N. Ren; S. Li; Z.Y. Li; X.Q. Shen; Y.Y. Yuan

doi:10.1177/2280800020975172

Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia

Y.M. Geng
, D.N. Ren
, S. Li
, Z.Y. Li
, X.Q. Shen
, Y.Y. Yuan

Maxillofacial Surgery (VUmc)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK.

METHODS: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls.

RESULTS: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the μ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants.

CONCLUSION: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.

Original language	English
Article number	2280800020975172
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Applied Biomaterials & Functional Materials
Volume	18
DOIs	https://doi.org/10.1177/2280800020975172
Publication status	Published - Jan 2020

Bibliographical note

Published online: 13 December 2020

Funding

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Key-Area Research and Development Program of Guangdong Province (No.2020B090924004).

Funders	Funder number
Special Project for Research and Development in Key areas of Guangdong Province	2020B090924004

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https://hdl.handle.net/11245.1/604b6bbf-11f4-4299-8196-71d96dcccad7

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@article{ba4a3ef4c0ae4a52a4488526ed8fb39c,

title = "Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia",

abstract = "BACKGROUND: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK.METHODS: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls.RESULTS: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the μ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants.CONCLUSION: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.",

author = "Y.M. Geng and D.N. Ren and S. Li and Z.Y. Li and X.Q. Shen and Y.Y. Yuan",

note = "Published online: 13 December 2020",

year = "2020",

month = jan,

doi = "10.1177/2280800020975172",

language = "English",

volume = "18",

pages = "1--9",

journal = "Journal of Applied Biomaterials \& Functional Materials",

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T1 - Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia

AU - Geng, Y.M.

AU - Ren, D.N.

AU - Li, S.

AU - Li, Z.Y.

AU - Shen, X.Q.

AU - Yuan, Y.Y.

N1 - Published online: 13 December 2020

PY - 2020/1

Y1 - 2020/1

N2 - BACKGROUND: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK.METHODS: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls.RESULTS: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the μ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants.CONCLUSION: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.

AB - BACKGROUND: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK.METHODS: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls.RESULTS: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the μ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants.CONCLUSION: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.

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DO - 10.1177/2280800020975172

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JO - Journal of Applied Biomaterials & Functional Materials

JF - Journal of Applied Biomaterials & Functional Materials

M1 - 2280800020975172

ER -

Hydroxyapatite-incorporation improves bone formation on endosseous PEEK implant in canine tibia

Abstract

Bibliographical note

Funding

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