Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

A. Becker, P.J. Kostense, G. Bos, R.J. Heine, J.M. Dekker, G. Nijpels, L.M. Bouter, C.D.A. Stehouwer

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    Abstract

    Objectives. Amongst nondiabetic individuals, a high serum homocysteine concentration is an independent but relatively weak risk factor for coronary events. However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events. Subjects. We assessed the 10-year risk of coronary events associated with homocysteine amongst diabetic (n = 140) and nondiabetic (n = 361) individuals. Design. We did this in the Hoorn Study, a population-based study of glucose tolerance and related complications in Caucasian men and women aged 50-75 years. Results. The incidence rate for coronary events was 2.63 (29 of 140) per 100 person-years amongst diabetic and 1.29 (42 of 361) amongst nondiabetic individuals. Amongst diabetic individuals, risk of coronary events increased 28% for each 5-μmol L
    Original languageEnglish
    Pages (from-to)293-300
    JournalJournal of Internal Medicine
    Volume253
    Issue number3
    DOIs
    Publication statusPublished - 2003

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