Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

A. Becker; P.J. Kostense; G. Bos; R.J. Heine; J.M. Dekker; G. Nijpels; L.M. Bouter; C.D.A. Stehouwer

doi:10.1046/j.1365-2796.2003.01113.x

Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

A. Becker
, P.J. Kostense
, G. Bos
, R.J. Heine
, J.M. Dekker
, G. Nijpels
, L.M. Bouter
, C.D.A. Stehouwer

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Objectives. Amongst nondiabetic individuals, a high serum homocysteine concentration is an independent but relatively weak risk factor for coronary events. However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events. Subjects. We assessed the 10-year risk of coronary events associated with homocysteine amongst diabetic (n = 140) and nondiabetic (n = 361) individuals. Design. We did this in the Hoorn Study, a population-based study of glucose tolerance and related complications in Caucasian men and women aged 50-75 years. Results. The incidence rate for coronary events was 2.63 (29 of 140) per 100 person-years amongst diabetic and 1.29 (42 of 361) amongst nondiabetic individuals. Amongst diabetic individuals, risk of coronary events increased 28% for each 5-μmol L

Original language	English
Pages (from-to)	293-300
Journal	Journal of Internal Medicine
Volume	253
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2796.2003.01113.x
Publication status	Published - 2003

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes",

abstract = "Objectives. Amongst nondiabetic individuals, a high serum homocysteine concentration is an independent but relatively weak risk factor for coronary events. However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events. Subjects. We assessed the 10-year risk of coronary events associated with homocysteine amongst diabetic (n = 140) and nondiabetic (n = 361) individuals. Design. We did this in the Hoorn Study, a population-based study of glucose tolerance and related complications in Caucasian men and women aged 50-75 years. Results. The incidence rate for coronary events was 2.63 (29 of 140) per 100 person-years amongst diabetic and 1.29 (42 of 361) amongst nondiabetic individuals. Amongst diabetic individuals, risk of coronary events increased 28\% for each 5-μmol L",

author = "A. Becker and P.J. Kostense and G. Bos and R.J. Heine and J.M. Dekker and G. Nijpels and L.M. Bouter and C.D.A. Stehouwer",

year = "2003",

doi = "10.1046/j.1365-2796.2003.01113.x",

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T1 - Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

AU - Becker, A.

AU - Kostense, P.J.

AU - Bos, G.

AU - Heine, R.J.

AU - Dekker, J.M.

AU - Nijpels, G.

AU - Bouter, L.M.

AU - Stehouwer, C.D.A.

PY - 2003

Y1 - 2003

N2 - Objectives. Amongst nondiabetic individuals, a high serum homocysteine concentration is an independent but relatively weak risk factor for coronary events. However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events. Subjects. We assessed the 10-year risk of coronary events associated with homocysteine amongst diabetic (n = 140) and nondiabetic (n = 361) individuals. Design. We did this in the Hoorn Study, a population-based study of glucose tolerance and related complications in Caucasian men and women aged 50-75 years. Results. The incidence rate for coronary events was 2.63 (29 of 140) per 100 person-years amongst diabetic and 1.29 (42 of 361) amongst nondiabetic individuals. Amongst diabetic individuals, risk of coronary events increased 28% for each 5-μmol L

AB - Objectives. Amongst nondiabetic individuals, a high serum homocysteine concentration is an independent but relatively weak risk factor for coronary events. However, it is not known whether homocysteine increases risk of coronary events in type 2 diabetes. Therefore, we examined the combined effect of homocysteine and type 2 diabetes on risk of fatal and nonfatal coronary events. Subjects. We assessed the 10-year risk of coronary events associated with homocysteine amongst diabetic (n = 140) and nondiabetic (n = 361) individuals. Design. We did this in the Hoorn Study, a population-based study of glucose tolerance and related complications in Caucasian men and women aged 50-75 years. Results. The incidence rate for coronary events was 2.63 (29 of 140) per 100 person-years amongst diabetic and 1.29 (42 of 361) amongst nondiabetic individuals. Amongst diabetic individuals, risk of coronary events increased 28% for each 5-μmol L

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U2 - 10.1046/j.1365-2796.2003.01113.x

DO - 10.1046/j.1365-2796.2003.01113.x

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SN - 0954-6820

VL - 253

SP - 293

EP - 300

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

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ER -

Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

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