Hyposmia and Executive Dysfunction as Predictors of Future Parkinson's Disease: A Prospective Study

M.M. Ponsen, D. Stoffers, J.W.R. Twisk, E.C.M.J. Wolters, H.W. Berendse

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder Society.
Original languageEnglish
Pages (from-to)1060-1065
Number of pages6
JournalMovement Disorders
Volume24
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Parkinson Disease
Prospective Studies
Executive Function
Parkinsonian Disorders

Bibliographical note

J AY 15

Cite this

Ponsen, M.M. ; Stoffers, D. ; Twisk, J.W.R. ; Wolters, E.C.M.J. ; Berendse, H.W. / Hyposmia and Executive Dysfunction as Predictors of Future Parkinson's Disease: A Prospective Study. In: Movement Disorders. 2009 ; Vol. 24, No. 7. pp. 1060-1065.
@article{5e1b40d2e4494a61b1ebae2adaa2ba4e,
title = "Hyposmia and Executive Dysfunction as Predictors of Future Parkinson's Disease: A Prospective Study",
abstract = "Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. {\circledC} 2009 Movement Disorder Society.",
author = "M.M. Ponsen and D. Stoffers and J.W.R. Twisk and E.C.M.J. Wolters and H.W. Berendse",
note = "J AY 15",
year = "2009",
doi = "10.1002/mds.22534",
language = "English",
volume = "24",
pages = "1060--1065",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

Hyposmia and Executive Dysfunction as Predictors of Future Parkinson's Disease: A Prospective Study. / Ponsen, M.M.; Stoffers, D.; Twisk, J.W.R.; Wolters, E.C.M.J.; Berendse, H.W.

In: Movement Disorders, Vol. 24, No. 7, 2009, p. 1060-1065.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Hyposmia and Executive Dysfunction as Predictors of Future Parkinson's Disease: A Prospective Study

AU - Ponsen, M.M.

AU - Stoffers, D.

AU - Twisk, J.W.R.

AU - Wolters, E.C.M.J.

AU - Berendse, H.W.

N1 - J AY 15

PY - 2009

Y1 - 2009

N2 - Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder Society.

AB - Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder Society.

U2 - 10.1002/mds.22534

DO - 10.1002/mds.22534

M3 - Article

VL - 24

SP - 1060

EP - 1065

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 7

ER -