Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene

C.D. Sandau; I.A.T.M. Meerts; R.J. Letcher; A.J. McAlee; B. Chittim; A. Brouwer; R.J. Norstrom

doi:10.1021/es001134f

Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene

C.D. Sandau
, I.A.T.M. Meerts
, R.J. Letcher
, A.J. McAlee
, B. Chittim
, A. Brouwer
, R.J. Norstrom

Research output: Contribution to Journal › Article › Academic › peer-review

258 Downloads (Pure)

Abstract

A new compound, 4-hydroxyheptachlorostyrene (4-OH-HpCS), was identified as a major component in the chlorinated phenolic compound fraction of polar bear plasma. The structure was hypothesized to be 4-OH-HpCS based on mass spectral interpretation, the assumption that it was a metabolite of octachlorostyrene, and the similarity of the structure to hydroxylated polychlorinated biphenyls (OH-PCBs) identified in plasma. High-resolution, electron impact (El) ionization mass spectrometry of the methylated compound indicated a molecular formula of C

Original language	English
Pages (from-to)	3871-3877
Journal	Environmental Science and Technology
Volume	34
Issue number	18
DOIs	https://doi.org/10.1021/es001134f
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Access to Document

10.1021/es001134f

130983Final published version, 146 KB

Persistent URL (handle)

Persistent link

Cite this

@article{07d69a778c9f41898aab25149aebf66b,

title = "Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene",

abstract = "A new compound, 4-hydroxyheptachlorostyrene (4-OH-HpCS), was identified as a major component in the chlorinated phenolic compound fraction of polar bear plasma. The structure was hypothesized to be 4-OH-HpCS based on mass spectral interpretation, the assumption that it was a metabolite of octachlorostyrene, and the similarity of the structure to hydroxylated polychlorinated biphenyls (OH-PCBs) identified in plasma. High-resolution, electron impact (El) ionization mass spectrometry of the methylated compound indicated a molecular formula of C",

author = "C.D. Sandau and I.A.T.M. Meerts and R.J. Letcher and A.J. McAlee and B. Chittim and A. Brouwer and R.J. Norstrom",

year = "2000",

doi = "10.1021/es001134f",

language = "English",

volume = "34",

pages = "3871--3877",

journal = "Environmental Science and Technology",

issn = "0013-936X",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene

AU - Sandau, C.D.

AU - Meerts, I.A.T.M.

AU - Letcher, R.J.

AU - McAlee, A.J.

AU - Chittim, B.

AU - Brouwer, A.

AU - Norstrom, R.J.

PY - 2000

Y1 - 2000

N2 - A new compound, 4-hydroxyheptachlorostyrene (4-OH-HpCS), was identified as a major component in the chlorinated phenolic compound fraction of polar bear plasma. The structure was hypothesized to be 4-OH-HpCS based on mass spectral interpretation, the assumption that it was a metabolite of octachlorostyrene, and the similarity of the structure to hydroxylated polychlorinated biphenyls (OH-PCBs) identified in plasma. High-resolution, electron impact (El) ionization mass spectrometry of the methylated compound indicated a molecular formula of C

AB - A new compound, 4-hydroxyheptachlorostyrene (4-OH-HpCS), was identified as a major component in the chlorinated phenolic compound fraction of polar bear plasma. The structure was hypothesized to be 4-OH-HpCS based on mass spectral interpretation, the assumption that it was a metabolite of octachlorostyrene, and the similarity of the structure to hydroxylated polychlorinated biphenyls (OH-PCBs) identified in plasma. High-resolution, electron impact (El) ionization mass spectrometry of the methylated compound indicated a molecular formula of C

U2 - 10.1021/es001134f

DO - 10.1021/es001134f

M3 - Article

SN - 0013-936X

VL - 34

SP - 3871

EP - 3877

JO - Environmental Science and Technology

JF - Environmental Science and Technology

IS - 18

ER -

Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene

Abstract

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this