Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

H. Mbarek, S. Steinberg, DR Nyholt, S.D. Gordon, M.B. Miller, A.F. McRae, J.J. Hottenga, F.R. Day, G. Willemsen, E.J.C. de Geus, G.E. Davies, H.C. Martin, B.W.J.H. Penninx, R. Jansen, K. McAloney, J.M. Vink, J. Kaprio, R. Plomin, T.D. Spector, P.K. MagnussonB. Reversade, R.A. Harris, K. Aagaard, R.P. Kristjansson, I. Olafsson, G.I. Eyjolfsson, O. Sigurdardottir, W.G. Iacono, C.B. Lambalk, G.W. Montgomery, M. McGue, K.K. Ong, J.R.B. Perry, N.G. Martin, H. Stefansson, K. Stefansson, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10
Original languageEnglish
Pages (from-to)898-908
JournalAmerican Journal of Human Genetics
Volume98
Issue number5
DOIs
Publication statusPublished - 2016

Fingerprint Dive into the research topics of 'Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility'. Together they form a unique fingerprint.

  • Cite this