Abstract
Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10
Original language | English |
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Pages (from-to) | 898-908 |
Journal | American Journal of Human Genetics |
Volume | 98 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2016 |
Cohort Studies
- Netherlands Twin Register (NTR)