Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

S. Kuhne, A.J. Kooistra, R. Bosma, A. Bortolato, M. Wijtmans, H.F. Vischer, J.S. Mason, C. de Graaf, I.J.P. de Esch, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)9047-9061
JournalJournal of Medicinal Chemistry
Volume59
Issue number19
DOIs
Publication statusPublished - 2016

Cite this

@article{0b9adb3683834767a25fcfc41b9b2e08,
title = "Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.",
author = "S. Kuhne and A.J. Kooistra and R. Bosma and A. Bortolato and M. Wijtmans and H.F. Vischer and J.S. Mason and {de Graaf}, C. and {de Esch}, I.J.P. and R. Leurs",
year = "2016",
doi = "10.1021/acs.jmedchem.6b00981",
language = "English",
volume = "59",
pages = "9047--9061",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "19",

}

Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization. / Kuhne, S.; Kooistra, A.J.; Bosma, R.; Bortolato, A.; Wijtmans, M.; Vischer, H.F.; Mason, J.S.; de Graaf, C.; de Esch, I.J.P.; Leurs, R.

In: Journal of Medicinal Chemistry, Vol. 59, No. 19, 2016, p. 9047-9061.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

AU - Kuhne, S.

AU - Kooistra, A.J.

AU - Bosma, R.

AU - Bortolato, A.

AU - Wijtmans, M.

AU - Vischer, H.F.

AU - Mason, J.S.

AU - de Graaf, C.

AU - de Esch, I.J.P.

AU - Leurs, R.

PY - 2016

Y1 - 2016

U2 - 10.1021/acs.jmedchem.6b00981

DO - 10.1021/acs.jmedchem.6b00981

M3 - Article

VL - 59

SP - 9047

EP - 9061

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 19

ER -