Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

S. Kuhne; A.J. Kooistra; R. Bosma; A. Bortolato; M. Wijtmans; H.F. Vischer; J.S. Mason; C. de Graaf; I.J.P. de Esch; R. Leurs

doi:10.1021/acs.jmedchem.6b00981

Identification of ligand binding hot spots of the histamine H₁ receptor following structure-based fragment optimization.

S. Kuhne
, A.J. Kooistra
, R. Bosma
, A. Bortolato
, M. Wijtmans
, H.F. Vischer
, J.S. Mason
, C. de Graaf
, I.J.P. de Esch
, R. Leurs

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	9047-9061
Journal	Journal of Medicinal Chemistry
Volume	59
Issue number	19
DOIs	https://doi.org/10.1021/acs.jmedchem.6b00981
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/acs.jmedchem.6b00981

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Cite this

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title = "Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.",

author = "S. Kuhne and A.J. Kooistra and R. Bosma and A. Bortolato and M. Wijtmans and H.F. Vischer and J.S. Mason and \{de Graaf\}, C. and \{de Esch\}, I.J.P. and R. Leurs",

year = "2016",

doi = "10.1021/acs.jmedchem.6b00981",

language = "English",

volume = "59",

pages = "9047--9061",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

AU - Kuhne, S.

AU - Kooistra, A.J.

AU - Bosma, R.

AU - Bortolato, A.

AU - Wijtmans, M.

AU - Vischer, H.F.

AU - Mason, J.S.

AU - de Graaf, C.

AU - de Esch, I.J.P.

AU - Leurs, R.

PY - 2016

Y1 - 2016

U2 - 10.1021/acs.jmedchem.6b00981

DO - 10.1021/acs.jmedchem.6b00981

M3 - Article

SN - 0022-2623

VL - 59

SP - 9047

EP - 9061

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 19

ER -