Idiopathic hyposmia as a preclinical sign of Parkinson's disease

M.M. Ponsen; D. Stoffers; J. Booij; B.L.F. Eck-Smit; E.C.M.J. Wolters; H.W. Berendse

doi:10.1002/ana.20160

Idiopathic hyposmia as a preclinical sign of Parkinson's disease

M.M. Ponsen, D. Stoffers, J. Booij, B.L.F. Eck-Smit, E.C.M.J. Wolters, H.W. Berendse

Clinical Neuropsychology

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Abstract

Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identification, and discrimination tasks was used to select groups of hyposmic (n = 40) and normosmic (n = 38) individuals for a 2-year clinical follow-up evaluation and sequential single-photon emission computed tomography (SPECT), using [

Original language	English
Pages (from-to)	173-181
Number of pages	9
Journal	Annals of Neurology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1002/ana.20160
Publication status	Published - 2004

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Ponsen Annals of Neurology 56(2) 2004 uFinal published version, 127 KB

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AU - Wolters, E.C.M.J.

AU - Berendse, H.W.

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Idiopathic hyposmia as a preclinical sign of Parkinson's disease

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