Idiopathic hyposmia as a preclinical sign of Parkinson's disease

M.M. Ponsen, D. Stoffers, J. Booij, B.L.F. Eck-Smit, E.C.M.J. Wolters, H.W. Berendse

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Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identification, and discrimination tasks was used to select groups of hyposmic (n = 40) and normosmic (n = 38) individuals for a 2-year clinical follow-up evaluation and sequential single-photon emission computed tomography (SPECT), using [
Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalAnnals of Neurology
Issue number2
Publication statusPublished - 2004


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