Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus

A.J. Borgers, A. Alkemade, E.M. Van de Giessen, M.L. Drent, J. Booij, P.H. Bisschop, E. Fliers

Research output: Contribution to JournalArticleAcademicpeer-review


Background: Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hypothalamus in vivo is difficult as delineation of the hypothalamus is cumbersome with conventional region-of-interest analysis. In the present study, we aimed to develop a method to visualize serotonin transporters (SERT) in the hypothalamus. Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C). Methods: SERT availability was determined in 17 subjects (6 HI, 5 PI, and 6 healthy controls), 2 h after injection of
Original languageEnglish
Pages (from-to)34
Number of pages7
JournalEJNMMI research
Issue number1
Publication statusPublished - 2013


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