Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus

A.J. Borgers; A. Alkemade; E.M. Van de Giessen; M.L. Drent; J. Booij; P.H. Bisschop; E. Fliers

doi:10.1186/2191-219X-3-34

Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus

A.J. Borgers
, A. Alkemade
, E.M. Van de Giessen
, M.L. Drent
, J. Booij
, P.H. Bisschop
, E. Fliers

Clinical Neuropsychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hypothalamus in vivo is difficult as delineation of the hypothalamus is cumbersome with conventional region-of-interest analysis. In the present study, we aimed to develop a method to visualize serotonin transporters (SERT) in the hypothalamus. Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C). Methods: SERT availability was determined in 17 subjects (6 HI, 5 PI, and 6 healthy controls), 2 h after injection of

Original language	English
Pages (from-to)	34
Number of pages	7
Journal	EJNMMI Research
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/2191-219X-3-34
Publication status	Published - 2013

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10.1186/2191-219X-3-34

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abstract = "Background: Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hypothalamus in vivo is difficult as delineation of the hypothalamus is cumbersome with conventional region-of-interest analysis. In the present study, we aimed to develop a method to visualize serotonin transporters (SERT) in the hypothalamus. Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C). Methods: SERT availability was determined in 17 subjects (6 HI, 5 PI, and 6 healthy controls), 2 h after injection of",

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AU - Borgers, A.J.

AU - Alkemade, A.

AU - Van de Giessen, E.M.

AU - Drent, M.L.

AU - Booij, J.

AU - Bisschop, P.H.

AU - Fliers, E.

PY - 2013

Y1 - 2013

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AB - Background: Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hypothalamus in vivo is difficult as delineation of the hypothalamus is cumbersome with conventional region-of-interest analysis. In the present study, we aimed to develop a method to visualize serotonin transporters (SERT) in the hypothalamus. Additionally, we tested the hypothesis that hypothalamic SERT binding ratios are different between patients with hypothalamic impairment (HI), pituitary insufficiency (PI), and control subjects (C). Methods: SERT availability was determined in 17 subjects (6 HI, 5 PI, and 6 healthy controls), 2 h after injection of

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VL - 3

SP - 34

JO - EJNMMI Research

JF - EJNMMI Research

IS - 1

ER -

Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus

Abstract

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