Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

B. Douradinha; M.R. van Dijk; G.J. Gemert; S.M. Khan; F. Janse; A.P. Waters; R.W. Sauerwein; A.J.F. Luty; B. Silva-Santos; M. Mota; S. Epiphanio

doi:10.1186/1476-8518-9-6

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

B. Douradinha, M.R. van Dijk, G.J. Gemert, S.M. Khan, F. Janse, A.P. Waters, R.W. Sauerwein, A.J.F. Luty, B. Silva-Santos, M. Mota, S. Epiphanio

Infectious Diseases

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Abstract

Background: The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mice immunized with radiation attenuated sporozoites (RAS) it has been shown that intrahepatic effector memory CD8

Original language	English
Journal	Journal of Immune Based Therapies and Vaccines
Volume	9
Issue number	6
Early online date	17 Oct 2011
DOIs	https://doi.org/10.1186/1476-8518-9-6
Publication status	Published - 2011

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10.1186/1476-8518-9-6

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Douradinha, B., van Dijk, M. R., Gemert, G. J., Khan, S. M., Janse, F., Waters, A. P., Sauerwein, R. W., Luty, A. J. F., Silva-Santos, B., Mota, M., & Epiphanio, S. (2011). Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver. Journal of Immune Based Therapies and Vaccines, 9(6). https://doi.org/10.1186/1476-8518-9-6

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title = "Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver",

abstract = "Background: The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mice immunized with radiation attenuated sporozoites (RAS) it has been shown that intrahepatic effector memory CD8",

author = "B. Douradinha and {van Dijk}, M.R. and G.J. Gemert and S.M. Khan and F. Janse and A.P. Waters and R.W. Sauerwein and A.J.F. Luty and B. Silva-Santos and M. Mota and S. Epiphanio",

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doi = "10.1186/1476-8518-9-6",

language = "English",

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journal = "Journal of Immune Based Therapies and Vaccines",

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Douradinha, B, van Dijk, MR, Gemert, GJ, Khan, SM, Janse, F, Waters, AP, Sauerwein, RW, Luty, AJF, Silva-Santos, B, Mota, M & Epiphanio, S 2011, 'Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver', Journal of Immune Based Therapies and Vaccines, vol. 9, no. 6. https://doi.org/10.1186/1476-8518-9-6

TY - JOUR

T1 - Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

AU - Douradinha, B.

AU - van Dijk, M.R.

AU - Gemert, G.J.

AU - Khan, S.M.

AU - Janse, F.

AU - Waters, A.P.

AU - Sauerwein, R.W.

AU - Luty, A.J.F.

AU - Silva-Santos, B.

AU - Mota, M.

AU - Epiphanio, S.

PY - 2011

Y1 - 2011

N2 - Background: The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mice immunized with radiation attenuated sporozoites (RAS) it has been shown that intrahepatic effector memory CD8

AB - Background: The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mice immunized with radiation attenuated sporozoites (RAS) it has been shown that intrahepatic effector memory CD8

U2 - 10.1186/1476-8518-9-6

DO - 10.1186/1476-8518-9-6

M3 - Article

SN - 1476-8518

VL - 9

JO - Journal of Immune Based Therapies and Vaccines

JF - Journal of Immune Based Therapies and Vaccines

IS - 6

ER -

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

Abstract

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