Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

B. Douradinha, M.R. van Dijk, G.J. Gemert, S.M. Khan, F. Janse, A.P. Waters, R.W. Sauerwein, A.J.F. Luty, B. Silva-Santos, M. Mota, S. Epiphanio

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Abstract

Background: The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mice immunized with radiation attenuated sporozoites (RAS) it has been shown that intrahepatic effector memory CD8
Original languageEnglish
JournalJournal of Immune Based Therapies and Vaccines
Volume9
Issue number6
Early online date17 Oct 2011
DOIs
Publication statusPublished - 2011

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