Abstract
The aim of the present study was to identify the site of prostaglandin E2 (PGE2) production in the brain in response to a pyrogenic dose of endotoxin. The presence of PGE2 was detected using immunocytochemistry on Bouin's fixed vibratome sections of control and endotoxin-treated rats. Peripheral administration of endotoxin caused a time-related stimulation of PGE2 immunoreactivity (irPGE2) in the choroid plexus and in the microvasculature of the brain. In addition to these sites, hypophysiotrophic neurons of the paraventricular nucleus (PVN) and supraopticus nucleus (SON) responded with induction of irPGE2 to endotoxin administration. Our data demonstrate that alterations in brain function in response to endotoxin may involve arachidonic metabolites such as PGE2 that are induced at the blood-brain barrier (microvasculature) and blood-liquor barrier (choroid plexus) and in hypophysiotrophic neurons of the rat brain.
| Original language | English |
|---|---|
| Pages (from-to) | 331-6 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 613 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 11 Jun 1993 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Brain/drug effects
- Cerebrovascular Circulation
- Dinoprostone/analysis
- Endotoxins/toxicity
- Immunohistochemistry/methods
- Male
- Microcirculation/drug effects
- Neurons/drug effects
- Organ Specificity
- Rats
- Rats, Wistar
- Reference Values
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